Martin J. Aryee

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

65h-index44.1kcitations203works9.92yr avg
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Research Topics

Epigenetics and DNA Methylation(60), CRISPR and Genetic Engineering(34), Single-cell and spatial transcriptomics(31), Genomics and Chromatin Dynamics(29), Cancer Genomics and Diagnostics(24)

Publications203 total

Integrating single-cell biophysical and transcriptomic features to resolve functional heterogeneity in mantle cell lymphoma
Science Advances·2025Open Access
Abstract B117: Intraductal Papillary Mucinous Neoplasm Cellular Plasticity Linked with Repeat Element Dysregulation
Cancer Research·2025
Bone Marrow Adipokine Mediates Hematopoietic Regeneration and Stem Cell Fitness
2025Open Access
Integrating Single-Cell Biophysical and Transcriptomic Features to Resolve Functional Heterogeneity in Mantle Cell Lymphoma
2025Open Access
High-resolution CTCF footprinting reveals impact of chromatin state on cohesin extrusion
Nature Communications·2025· 6 citedOpen Access
1563 Assessment of Lorlatinib Resistance in ALK-Positive Non-Small Cell Lung Cancer Patient Samples Using Spatial Transcriptomics
Laboratory Investigation·2025Open Access
Intraductal Papillary Mucinous Neoplasm Cellular Plasticity is Linked with Repeat Element Dysregulation
2025Open Access
Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
Cell·2024· 17 citedOpen Access
HCC spatial transcriptomic profiling reveals significant and potentially targetable cancer-endothelial interactions
Hepatology Communications·2024· 4 citedOpen Access
Risk of bleeding in patients with essential thrombocythemia and extreme thrombocytosis
Blood Advances·2024· 8 citedOpen Access
Abstract B091: Spatial Transcriptomics Unveils Intraductal Papillary Mucinous Neoplasm Heterogeneity: From Novel Clusters to Immune Dynamics
Cancer Research·2024
Abstract A039: Repeat RNA mediated disruption of cellular plasticity in pancreatic cancer
Cancer Research·2024
Detection of allele-specific expression in spatial transcriptomics with spASE
Genome biology·2024· 11 citedOpen Access
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification
Immunity·2024· 15 citedOpen Access
Abstract 786: Genomic distinctions of HIV- and EBV-associated DLBCL in a diverse African cohort
Cancer Research·2024
Abstract 1134: Dissecting pancreatic cancer tumor-immune microenvironment crosstalk using spatial transcriptomics
Cancer Research·2024
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
Nature Immunology·2024· 107 citedOpen Access
Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma
2023· 1 citedOpen Access
No Increased Incidence of Bleeding in Essential Thrombocythemia Patients with Extreme Thrombocytosis
Blood·2023· 1 citedOpen Access
<i>TP53</i> mutations and Their Impact on Survival in Patients with Myeloproliferative Neoplasms
Blood·2023· 3 cited
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Frequent Co-authors

Caleb A. Lareau(14), J. Keith Joung(12), Andrew P. Feinberg(10), Rafael A. Irizarry(10), Shengdar Q. Tsai(7), Jason D. Buenrostro(7), Peter Murakami(5), Nathalie T. Nguyen(5), Benjamin P. Kleinstiver(5), Sara P. Garcia(5), Sowmya Iyer(5), Akiko Doi(4), George Q. Daley(4), Vishal Thapar(4), Jose Malagon-Lopez(4), Luca Pinello(4), Srinivasan Yegnasubramanian(4), Leif S. Ludwig(4), Aviv Regev(4), Vijay G. Sankaran(4)