James H. McKerrow

University of California, San Diego — United States

Medicine · Health Sciences

93h-index27.8kcitations416works0.32yr avg
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Research Topics

Research on Leishmaniasis Studies(133), Trypanosoma species research and implications(129), Parasites and Host Interactions(110), Parasite Biology and Host Interactions(58), Synthesis and Biological Evaluation(32)

Publications413 total

Identification of Substituted 4-Aminocinnolines as Broad-Spectrum Antiparasitic Agents
ACS Infectious Diseases·2025Open Access
Computational Workflow to Design Novel Vaccine Candidates and Small-Molecule Therapeutics for Schistosomiasis
Pathogens·2024· 1 citedOpen Access
A Single-dose Phase 1 Study With SLV213 Demonstrates Safety and Pharmacokinetics Enabling Investigation of a New Orally Available Cathepsin L Inhibitor for Treatment of Patients With Respiratory Diseases
2024
Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines
Parasitology Research·2023· 13 citedOpen Access
Molecular identification of phlebotomine sand flies and the harbored Leishmania spp. in Sokoto State, Nigeria
Frontiers in Cellular and Infection Microbiology·2023· 2 citedOpen Access
The importance of good practices and false hits for QSAR-driven virtual screening real application: a SARS-CoV-2 main protease (Mpro) case study
Frontiers in Drug Discovery·2023· 8 citedOpen Access
Structure-Based Discovery of Thiosemicarbazones As SARS-CoV-2 Main Protease Inhibitors
Future Medicinal Chemistry·2023· 12 cited
Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of Leishmania infection
Frontiers in Tropical Diseases·2023· 8 citedOpen Access
Coumarin-based derivatives targeting<i>Trypanosoma cruzi</i>cruzain and<i>Trypanosoma brucei</i>cathepsin L-like proteases
New Journal of Chemistry·2023· 8 cited
Identification of Novel Genes and Proteoforms in Angiostrongylus costaricensis through a Proteogenomic Approach
Pathogens·2022· 5 citedOpen Access
Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease M <sup>pro</sup> and Papain-like Protease PL <sup>pro</sup> of SARS-CoV-2
Journal of Chemical Information and Modeling·2022· 40 cited
Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure–Activity Relationships, Antiviral Activity, and X-ray Structure Determination
Journal of Medicinal Chemistry·2022· 66 citedOpen Access
Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L
Pharmaceuticals·2022· 15 citedOpen Access
Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against <i>Trypanosoma cruzi</i>
Journal of Medicinal Chemistry·2022· 20 citedOpen Access
Identification of Leucinostatins from <i>Ophiocordyceps</i> sp. as Antiparasitic Agents against <i>Trypanosoma cruzi</i>
ACS Omega·2022· 8 citedOpen Access
Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2
2022· 7 citedOpen Access
Intramolecular interactions enhance the potency of gallinamide A analogs against <i>Trypanosoma cruzi</i>
2021Open Access
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L
Journal of Medicinal Chemistry·2021· 80 citedOpen Access
Discovery of Potent Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L
2021· 1 citedOpen Access
Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas Disease
PLoS neglected tropical diseases·2021· 33 citedOpen Access
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Frequent Co-authors

Elizabeth Hansell(8), Mohammed Sajid(7), Patricia S. Doyle(7), Juan C. Engel(7), Conor R. Caffrey(6), Philip J. Rosenthal(5), Charles S. Craik(5), Jiří Gut(5), Ivy Hsieh(4), Adam R. Renslo(3), Fred E. Cohen(3), Sharon L. Reed(3), Kee‐Chong Lim(3), Judy A. Sakanari(3), P’ng Loke(2), Eugene Sun(2), Philip Rosenthal(2), Anjan Debnath(2), Steven Chen(2), Michelle R. Arkin(2)