Juan C. Engel

University of California, San Francisco — United States

Medicine · Health Sciences

40h-index5.4kcitations78works0.02yr avg
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Research Topics

Trypanosoma species research and implications(59), Research on Leishmaniasis Studies(35), Biochemical and Molecular Research(17), Synthesis and Biological Evaluation(13), Toxoplasma gondii Research Studies(9)

Publications78 total

Mechanistic Exploration of N,N′-Disubstituted Diamines as Promising Chagas Disease Treatments
Pharmaceuticals·2026Open Access
A specific reagent to study trypanosomatids respiration through polyprenyl diphosphate synthases inhibition: 1-[(n-oct-1-ylamino) ethyl] 1,1-bisphosphonic acid.
Interamerican Journal of Health Sciences·2023Open Access
Cell Biology of Pathogenic Protozoa and Their Interaction with Host Cells
BioMed Research International·2014· 1 citedOpen Access
Diversity-Oriented Synthesis Yields a New Drug Lead for Treatment of Chagas Disease
ACS Medicinal Chemistry Letters·2013· 41 citedOpen Access
Identification of Diversity-Oriented Synthesis Derived Small Molecule, ML341, with Cidal Activity Against Trypanosoma cruzi
2013· 3 cited
Heme-Regulated Inhibitor (HRI) eIF2α Kinase and the Heme-Regulated Turnover of Cytochromes P450 and Other Hepatic Proteins
Handbook of porphyrin science·2013· 1 cited
Contribution to New Therapies for Chagas Disease
2013· 2 cited
Host Metabolism Regulates Intracellular Growth of Trypanosoma cruzi
Cell Host & Microbe·2013· 122 citedOpen Access
Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51
PLoS neglected tropical diseases·2012· 65 citedOpen Access
The Trypanosoma cruzi Protease Cruzain Mediates Immune Evasion
PLoS Pathogens·2011· 120 citedOpen Access
A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit
PLoS neglected tropical diseases·2011· 219 citedOpen Access
Temporal Analysis of the Honey Bee Microbiome Reveals Four Novel Viruses and Seasonal Prevalence of Known Viruses, Nosema, and Crithidia
PLoS ONE·2011· 446 citedOpen Access
Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads
PLoS neglected tropical diseases·2011· 53 citedOpen Access
Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation
Journal of Biological Chemistry·2010· 21 citedOpen Access
Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases
Journal of Biological Chemistry·2010· 37 citedOpen Access
Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of <i>Trypanosoma cruzi</i> , the Agent of Chagas' Disease
Antimicrobial Agents and Chemotherapy·2010· 105 citedOpen Access
A Nonazole CYP51 Inhibitor Cures Chagas’ Disease in a Mouse Model of Acute Infection
Antimicrobial Agents and Chemotherapy·2010· 65 citedOpen Access
Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy
Journal of Medicinal Chemistry·2010· 132 citedOpen Access
Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes
Molecular and Biochemical Parasitology·2009· 18 cited
A Contiguous Compartment Functions as Endoplasmic Reticulum and Endosome/Lysosome in <i>Giardia lamblia</i>
Eukaryotic Cell·2009· 84 citedOpen Access
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Frequent Co-authors

James H. McKerrow(23), Patricia S. Doyle(11), James A. Dvorak(7), Ivy Hsieh(6), Linda S. Brinen(5), Elizabeth Hansell(5), Kenny K. H. Ang(4), Michelle R. Arkin(4), Xuchu Que(4), Sharon L. Reed(4), Ann E. Eakin(3), Steven Chen(3), Mohammed Sajid(3), Jiří Gut(3), Joseph L. DeRisi(2), Doron C. Greenbaum(2), Matthew Bogyo(2), Charles S. Craik(2), Juan José Cazzulo(2), Berta M. Franke de Cazzulo(2)