Doron C. Greenbaum

Discovery Institute — United States

Medicine · Health Sciences

38h-index7.7kcitations50works0.02yr avg
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Research Topics

Malaria Research and Control(11), Peptidase Inhibition and Analysis(11), Biochemical and Structural Characterization(10), Trypanosoma species research and implications(6), Chemical Synthesis and Analysis(6)

Publications50 total

Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors
PLoS ONE·2015· 18 citedOpen Access
Thioamide-Based Fluorescent Protease Sensors
Journal of the American Chemical Society·2014· 54 citedOpen Access
A Host GPCR Signaling Network Required for the Cytolysis of Infected Cells Facilitates Release of Apicomplexan Parasites
Cell Host & Microbe·2013· 42 citedOpen Access
Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design
Proceedings of the National Academy of Sciences·2012· 105 citedOpen Access
Platelet Factor 4 Activity against P. falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials
Cell Host & Microbe·2012· 86 citedOpen Access
Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction
Journal of the American Chemical Society·2012· 254 citedOpen Access
OspC Is Potent Plasminogen Receptor on Surface of Borrelia burgdorferi
Journal of Biological Chemistry·2012· 115 citedOpen Access
The Malaria Parasite Progressively Dismantles the Host Erythrocyte Cytoskeleton for Efficient Egress
Molecular & Cellular Proteomics·2011· 76 citedOpen Access
The Trypanosoma cruzi Protease Cruzain Mediates Immune Evasion
PLoS Pathogens·2011· 120 citedOpen Access
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
Proceedings of the National Academy of Sciences·2011· 140 citedOpen Access
Substrate specificity of Staphylococcus aureus cysteine proteases – Staphopains A, B and C
Biochimie·2011· 24 citedOpen Access
Synthesis of New (−)-Bestatin-Based Inhibitor Libraries Reveals a Novel Binding Mode in the S1 Pocket of the Essential Malaria M1 Metalloaminopeptidase
Journal of Medicinal Chemistry·2011· 65 citedOpen Access
Discovery of Potent Small-Molecule Inhibitors of Multidrug-Resistant <i>Plasmodium falciparum</i> Using a Novel Miniaturized High-Throughput Luciferase-Based Assay
Antimicrobial Agents and Chemotherapy·2010· 47 citedOpen Access
A Small-Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T cells
Molecular Pharmacology·2010· 121 citedOpen Access
Platelets, Pyrexia, and Plasmodia
New England Journal of Medicine·2009· 25 cited
Apicomplexan Parasites Co-Opt Host Calpains to Facilitate Their Escape from Infected Cells
Science·2009· 148 cited
Signal peptide peptidases: A family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins
Seminars in Cell and Developmental Biology·2009· 62 citedOpen Access
Membrane Disrupting Antimicrobial Peptide Mimics as Antimalarial Therapeutics
46th Annual Meeting·2008
Development of bestatin-based activity-based probes for metallo-aminopeptidases
Bioorganic & Medicinal Chemistry Letters·2008· 39 citedOpen Access
Proteases' prime targets revealed
Nature Biotechnology·2008· 1 cited
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Frequent Co-authors

Matthew Bogyo(21), Amos Baruch(6), Katalin F. Medzihradszky(6), Michael B. Harbut(6), Thomas Toneff(5), Vivian Hook(5), Tyler Jacks(4), James H. McKerrow(4), William S. Lane(4), Rajesh Chandramohanadas(4), Geetha Velmourougane(4), Leisa Johnson(3), Kim L. Mercer(3), Alma L. Burlingame(3), Karen Cichowski(3), H Umanoff(3), W Edelmann(3), Dieter Brömme(3), Hyunil Jo(3), Nataline Meinhardt(3)