Doron C. Greenbaum

Discovery Institute — United States

Medicine · Health Sciences

38h-index7.7kcitations50works0.02yr avg
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Research Topics

Malaria Research and Control(11), Peptidase Inhibition and Analysis(11), Biochemical and Structural Characterization(10), Trypanosoma species research and implications(6), Chemical Synthesis and Analysis(6)

Publications50 total

Development of Potent Purine-Derived Nitrile Inhibitors of the Trypanosomal Protease TbcatB
Journal of Medicinal Chemistry·2008· 58 citedOpen Access
Identification of protein complexes in detergent-resistant membranes of Plasmodium falciparum schizonts
Molecular and Biochemical Parasitology·2007· 79 cited
Development of Calpain-specific Inactivators by Screening of Positional Scanning Epoxide Libraries
Journal of Biological Chemistry·2007· 40 citedOpen Access
Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities
Journal of Biological Chemistry·2006· 418 citedOpen Access
INHIBITORS OF CATHEPSIN B REDUCE PRODUCTION OF BETA‐AMYLOID IN REGULATED SECRETORY VESICLES: A NOVEL CYSTEINE PROTEASE PATHWAY AS BETA‐SECRETASE FOR GENERATING BETA‐AMYLOID OF ALZHEIMER'S DISEASE
The FASEB Journal·2006
Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally
2006
Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease
Biological Chemistry·2005· 51 cited
Distinct Protein Classes Including Novel Merozoite Surface Antigens in Raft-like Membranes of Plasmodium falciparum
Journal of Biological Chemistry·2005· 224 citedOpen Access
Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease
Biological Chemistry·2005· 168 cited
A Cathepsin B-like Protease Is Required for Host Protein Degradation in Trypanosoma brucei
Journal of Biological Chemistry·2004· 105 citedOpen Access
Cathepsin V, a Novel and Potent Elastolytic Activity Expressed in Activated Macrophages
Journal of Biological Chemistry·2004· 194 citedOpen Access
Targeted disruption of <i>Plasmodium falciparum</i> cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth
Molecular Microbiology·2004· 90 citedOpen Access
Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against <i>Plasmodium falciparum</i>, <i>Trypanosoma brucei</i>, and <i>Trypanosoma cruzi</i>
Journal of Medicinal Chemistry·2004· 249 citedOpen Access
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
Cancer Cell·2004· 627 citedOpen Access
Applications for Chemical Probes of Proteolytic Activity
Current Protocols in Protein Science·2004· 9 cited
O-Sulfonation of Serine and Threonine
Molecular & Cellular Proteomics·2004· 136 citedOpen Access
Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones
Biological Chemistry·2004· 74 cited
Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis
Biological Chemistry·2004· 30 citedOpen Access
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter
Proceedings of the National Academy of Sciences·2003· 210 citedOpen Access
A Role for the Protease Falcipain 1 in Host Cell Invasion by the Human Malaria Parasite
Science·2002· 285 cited
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Frequent Co-authors

Matthew Bogyo(21), Amos Baruch(6), Katalin F. Medzihradszky(6), Michael B. Harbut(6), Thomas Toneff(5), Vivian Hook(5), Tyler Jacks(4), James H. McKerrow(4), William S. Lane(4), Rajesh Chandramohanadas(4), Geetha Velmourougane(4), Leisa Johnson(3), Kim L. Mercer(3), Alma L. Burlingame(3), Karen Cichowski(3), H Umanoff(3), W Edelmann(3), Dieter Brömme(3), Hyunil Jo(3), Nataline Meinhardt(3)