Charles A. Swofford

Massachusetts Institute of Technology — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index589citations19works6.32yr avg
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Research Topics

Cancer Research and Treatments(11), Bacteriophages and microbial interactions(9), Virus-based gene therapy research(6), Nanoplatforms for cancer theranostics(5), Microbial Metabolic Engineering and Bioproduction(5)

Publications19 total

The effect on shikimate production by deleting iolR and metabolic engineering in PTS deficient Corynebacterium glutamicum strain
Frontiers in Bioengineering and Biotechnology·2025Open Access
A sensitive sample preparation pipeline for adventitious virus detection using Oxford Nanopore sequencing
Molecular Therapy — Methods & Clinical Development·2025Open Access
Engineering carbon source division of labor for efficient α-carotene production in Corynebacterium glutamicum
Metabolic Engineering·2024· 19 cited
Structure and specificity of an <scp>anti‐chloramphenicol</scp> single domain antibody for detection of amphenicol residues
Protein Science·2022· 8 citedOpen Access
Heterologous production of α-Carotene in Corynebacterium glutamicum using a multi-copy chromosomal integration method
Bioresource Technology·2021· 36 cited
Optimizing recombineering in <i>Corynebacterium glutamicum</i>
Biotechnology and Bioengineering·2021· 17 citedOpen Access
DESIGN OF A TARGETED BACTERIAL DRUG DELIVERY VECTOR FOR THE TREATMENT OF CANCER AND METASTASES
Scholarworks (University of Massachusetts Amherst)·2020Open Access
Modular engineering for microbial production of carotenoids
Metabolic Engineering Communications·2019· 126 citedOpen Access
DEVELOPMENT OF RAPID GENOME ENGINEERING TOOLS FOR CORYNEBACTERIUM GLUTAMICUM
2017 AAAS Annual Meeting (February 16-20, 2017)·2017
Microfluidic Device to Quantify the Behavior of Therapeutic Bacteria in Three-Dimensional Tumor Tissue
Methods in molecular biology·2016· 5 citedOpen Access
Abstract 3538: Quorum-sensing Salmonella selectively trigger protein expression within tumors
Cancer Research·2015· 3 cited
Potent and Tumor specific: Arming Bacteria With Therapeutic Proteins
Therapeutic Delivery·2015· 47 citedOpen Access
Quorum-sensing <i>Salmonella</i> selectively trigger protein expression within tumors
Proceedings of the National Academy of Sciences·2015· 137 citedOpen Access
Bacterial Delivery of Staphylococcus aureus α-Hemolysin Causes Regression and Necrosis in Murine Tumors
Molecular Therapy·2014· 93 citedOpen Access
Identification of <i>Staphylococcus aureus</i> α‐hemolysin as a protein drug that is secreted by anticancer bacteria and rapidly kills cancer cells
Biotechnology and Bioengineering·2014· 40 cited
Lipid A controls the robustness of intratumoral accumulation of attenuated<i>Salmonella</i>in mice
International Journal of Cancer·2013· 21 citedOpen Access
Construction of an inducible cell‐communication system that amplifies <i>Salmonella</i> gene expression in tumor tissue
Biotechnology and Bioengineering·2012· 32 cited
Abstract 5649: Quorum-sensing salmonella selectively trigger protein expression within tumor models
Cancer Research·2012· 1 cited
Abstract 5658: Engineered Salmonella effectively produce and preferentially deliver bacterial cytotoxins to solid tumors
Cancer Research·2012· 4 cited

Frequent Co-authors

Neil S. Forbes(10), Anthony J. Sinskey(4), Nele Van Dessel(3), Adam St. Jean(3), Zachary J. Brentzel(3), Anthony J. Sinskey(3), Cheng Li(2), Jan T. Panteli(2), Christian Rückert(2), Rui Wen Ou(2), Gregory Stephanopoulos(2), Bhushan J. Toley(2), Cheng Li(2), Stacy L. Springs(2), Alkiviadis Orfefs Chatzivasileiou(1), Patrick Opdensteinen(1), Tobias Luttermann(1), Kang Zhou(1), Kristala L. J. Prather(1), En Ze Linda Zhong-Johnson(1)