Simon P. Fletcher

Medicine · Health Sciences

35h-index4.4kcitations98works6.02yr avg
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Research Topics

Hepatitis B Virus Studies(66), Hepatitis C virus research(56), Liver Disease Diagnosis and Treatment(33), Immune Response and Inflammation(14), Immunotherapy and Immune Responses(10)

Publications97 total

Spatial transcriptional profiling of CHB liver biopsies reveals an undetected population of zonally biased HBV-integrated cells.
JHEP Reports·2026Open Access
Tracking B cell immunity during perturbation of hepatitis B infection induced by treatment withdrawal
Gut·2025· 1 citedOpen Access
A highly selective TCR-mimic antibody reveals unexpected mechanisms of HBV peptide-MHC recognition and previously unknown target biology
mAbs·2025Open Access
Identification and engineering of potent bispecific antibodies that protect against herpes simplex virus recurrent disease
Cell Reports·2025· 2 citedOpen Access
Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys
Nature Communications·2025· 2 citedOpen Access
Association between herpes simplex virus type 1 and the risk of Alzheimer’s disease: a retrospective case–control study
BMJ Open·2025· 10 citedOpen Access
SAT-310 Immune profiling of peripheral and intrahepatic B cells in chronic hepatitis B
Journal of Hepatology·2025
Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys
2025· 1 citedOpen Access
Understanding and Targeting HBV Transcription and Post-Transcriptional Regulation
Viruses·2024Open Access
Hepatitis D virus infection triggers CXCL9-11 upregulation in hepatocytes and liver infiltration of CXCR3+ CD4 T cells
JHEP Reports·2024Open Access
Circulating HBsAg-specific B cells are partially rescued in chronically HBV-infected patients with functional cure
UNC Libraries·2024Open Access
Circulating HBsAg-specific B cells are partially rescued in chronically HBV-infected patients with functional cure
Emerging Microbes & Infections·2024· 5 citedOpen Access
Effects of tenofovir disoproxil fumarate on intrahepatic viral burden and liver immune microenvironment in patients with chronic hepatitis B
Gut·2024· 15 citedOpen Access
HBcrAg values may predict virological and immunological responses to pegIFN-α in NUC-suppressed HBeAg-negative chronic hepatitis B
Gut·2024· 15 citedOpen Access
eQTLs identify regulatory networks and drivers of variation in the individual response to sepsis
Cell Genomics·2024· 15 citedOpen Access
High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response
Science Translational Medicine·2024· 45 citedOpen Access
SAT-342-YI PegIFNα treatment in NUC-suppressed HBV/HDV-infected mice with high numbers of HDV-monoinfected cells reduces HDV infection below the limit of quantification
Journal of Hepatology·2024
FRI-373 Impact of pregnancy on global and HBV-specific B-cell immunity
Journal of Hepatology·2024
OS-091 Precision-cut liver slices as a pre-clinical model for the evaluation of host-targeting agents against hepatitis B virus and hepatitis delta virus infection
Journal of Hepatology·2024
Selective depletion of HBV-infected hepatocytes by class A capsid assembly modulators requires high levels of intrahepatic HBV core protein
Antimicrobial Agents and Chemotherapy·2024· 4 citedOpen Access
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Frequent Co-authors

Stéphane Daffis(11), Rudolf K. Beran(9), Li Li(9), William E. Delaney(8), Dhivya Ramakrishnan(7), Anuj Gaggar(7), Congrong Niu(6), Jasmeet Soar(6), Fabien Zoulim(6), Becket Feierbach(6), Christine M. Livingston(5), Stephan Menne(5), Dara Burdette(5), Julie Lucifora(5), Ricardo Ramírez(5), Jeffrey J. Wallin(5), Michel Strubin(4), Magdeleine Hung(4), Lisa Bauman(4), D R Averett(4)