Alain R. Baulard

Centre National de la Recherche Scientifique — France

Medicine · Health Sciences

39h-index5.1kcitations102works2.22yr avg
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Research Topics

Tuberculosis Research and Epidemiology(64), Cancer therapeutics and mechanisms(36), Mycobacterium research and diagnosis(34), Biochemical and Molecular Research(22), Pneumocystis jirovecii pneumonia detection and treatment(8)

Publications102 total

Exploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill <i>Mycobacterium tuberculosis</i>
2025Open Access
Alanine dependence of trans-translation contributes to riboregulation of mycobacterial antibiotic recalcitrance genes
2025Open Access
Pyrazinamide kills <i>Mycobacterium tuberculosis</i> via pH-driven weak-acid permeation and cytosolic acidification
2025· 2 citedOpen Access
Assessment of Innovative Dry Powders for Inhalation of a Synergistic Combination Against Mycobacterium tuberculosis in Infected Macrophages and Mice
Pharmaceutics·2025Open Access
Speeding up drug susceptibility testing in Mycobacterium tuberculosis using RNA biomarkers
EBioMedicine·2025· 1 citedOpen Access
Exploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis
SSRN Electronic Journal·2025Open Access
Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase
iScience·2024· 4 citedOpen Access
Crystal structure of the Mycobacterium tuberculosis VirS regulator reveals its interaction with the lead compound SMARt751
Journal of Structural Biology·2024Open Access
Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system
Cell chemical biology·2024· 13 cited
Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway
Journal of Medicinal Chemistry·2023· 9 citedOpen Access
Loss-of-function mutations in <i>ndh</i> do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in <i>Mycobacterium tuberculosis</i>
Antimicrobial Agents and Chemotherapy·2023· 7 citedOpen Access
Optimizing the use of current antituberculosis drugs to overcome drug resistance in Mycobacterium tuberculosis
Infectious Diseases Now·2023· 12 cited
Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification
Pharmaceuticals·2023· 3 citedOpen Access
The small-molecule SMARt751 reverses <i>Mycobacterium tuberculosis</i> resistance to ethionamide in acute and chronic mouse models of tuberculosis
Science Translational Medicine·2022· 27 citedOpen Access
On the Hunt for Next-Generation Antimicrobial Agents: An Online Symposium Organized Jointly by the French Society for Medicinal Chemistry (Société de Chimie Thérapeutique) and the French Microbiology Society (Société Française de Microbiologie) on 9–10 December 2021
Pharmaceuticals·2022Open Access
The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis
The Lancet Microbe·2022· 282 citedOpen Access
Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening
European Journal of Medicinal Chemistry·2020· 22 citedOpen Access
Fragment-Based Optimized EthR Inhibitors with <i>in Vivo</i> Ethionamide Boosting Activity
ACS Infectious Diseases·2020· 20 citedOpen Access
Cpn60.1 (GroEL1) Contributes to Mycobacterial Crabtree Effect: Implications for Biofilm Formation
Frontiers in Microbiology·2019· 15 citedOpen Access
Intrinsic Antibacterial Activity of Nanoparticles Made of β-Cyclodextrins Potentiates Their Effect as Drug Nanocarriers against Tuberculosis
ACS Nano·2019· 67 citedOpen Access
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Frequent Co-authors

Camille Locht(21), Nicolas Willand(15), Benoît Déprez(14), Priscille Brodin(13), Gurdyal S. Besra(10), Marion Flipo(10), Laurent Kremer(9), Vincent Villeret(9), Patrick J. Brennan(7), Vincent Delorme(7), René Wintjens(7), Baptiste Villemagne(6), Matthieu Desroses(6), Florence Leroux(6), Vanessa Mathys(5), Alexandre Wohlkönig(5), Nathalie Lecat‐Guillet(5), Catherine Piveteau(5), Jean Engohang‐Ndong(4), Bertrand Dirié(4)