Richard J. Smeyne

Medicine · Health Sciences

62h-index15.2kcitations155works2.22yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(38), Neuroscience and Neuropharmacology Research(28), Neuroinflammation and Neurodegeneration Mechanisms(24), Nerve injury and regeneration(23), Neurogenesis and neuroplasticity mechanisms(19)

Publications152 total

Templating of monomeric alpha-synuclein results in inflammation and SNpc dopamine neuron death in a genetic mouse model of induced synucleinopathy
Scientific Reports·2025· 4 citedOpen Access
Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection
npj Parkinson s Disease·2025· 2 citedOpen Access
Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection
2024Open Access
Templating of Monomeric Alpha-Synuclein Induces Inflammation and SNpc Dopamine Neuron Death in a Genetic Mouse Model of Synucleinopathy.
2024Open Access
Templating of Monomeric Alpha-Synuclein Induces Inflammation and SNpc Dopamine Neuron Death in a Genetic Mouse Model of Synucleinopathy
2024Open Access
GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults
npj Parkinson s Disease·2024· 7 citedOpen Access
In memorium, Michael Zigmond, PhD
npj Parkinson s Disease·2023Open Access
GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults
2023· 1 citedOpen Access
Neuroanatomical and neurochemical effects of prolonged social isolation in adult mice
Frontiers in Neuroanatomy·2023· 4 citedOpen Access
Microglia‐specific knock‐out of <scp>NF‐κB</scp>/<scp>IKK2</scp> increases the accumulation of misfolded α‐synuclein through the inhibition of p62/<scp>sequestosome</scp>‐1‐dependent autophagy in the rotenone model of Parkinson's disease
Glia·2023· 40 citedOpen Access
Neurobiological and Behavioral Characterization of Adult Male and Female Mice in Prolonged Social Isolation
2022Open Access
Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment
Nature Aging·2022· 51 citedOpen Access
The impact of isolation on brain health
Elsevier eBooks·2022
<scp>COVID</scp> ‐19 Infection Enhances Susceptibility to Oxidative Stress–Induced Parkinsonism
Movement Disorders·2022· 28 citedOpen Access
Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson’s disease
npj Parkinson s Disease·2022· 36 citedOpen Access
Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice
Neurobiology of Disease·2022· 75 citedOpen Access
COVID-19 infection enhances susceptibility to oxidative-stress induced parkinsonism
2022· 3 citedOpen Access
Astrocyte inflammatory signaling mediates α-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis
Experimental Neurology·2021· 29 citedOpen Access
Effect of Chronic Methylphenidate Treatment in a Female Experimental Model of Parkinsonism
Neurotoxicity Research·2021· 1 cited
Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus
PLoS ONE·2021· 10 citedOpen Access
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Frequent Co-authors

James P. Morgan(7), Amar K. Pani(7), Tom Curran(6), Yun Jiao(6), Mariano Barbacid(5), John Oberdick(5), Karl Schilling(4), Haeman Jang(4), Rüdiger Klein(3), Sérgio A. Lira(3), Inmaculada Silos‐Santiago(3), David A. Boltz(3), Robert G. Webster(3), Ciaran Faherty(3), Frédérique Zindy(3), Justine J. Cunningham(3), Shankar Sadasivan(3), Linda K. Long(2), Sherri Bryant(2), Anne Lewin(2)