Nicolai S. C. van Oers

Southwestern Medical Center — United States

Immunology and Microbiology · Life Sciences

37h-index5.4kcitations129works0.92yr avg
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Research Topics

T-cell and B-cell Immunology(45), Immune Cell Function and Interaction(45), Monoclonal and Polyclonal Antibodies Research(14), Congenital heart defects research(14), Immunotherapy and Immune Responses(13)

Publications129 total

Clinical Variance in an International Cohort of Families with Dominant-Negative FOXN1 Mutations
Journal of Human Immunity·2025Open Access
The ClinGen Severe Combined Immunodeficiency Disease Variant Curation Expert Panel: Specifications for classification of variants in ADA, DCLRE1C, IL2RG, IL7R, JAK3, RAG1, and RAG2
Genetics in Medicine·2025· 1 citedOpen Access
The systemic effects of 22q11.2 deletion syndrome on immunity
Journal of Human Immunity·2025· 2 citedOpen Access
Minoxidil restores thymic growth in 22q11.2 deletion syndrome by limiting Sox9+ chondrocyte expansion
Journal of Human Immunity·2025· 1 citedOpen Access
Informed clinical decisions by outfoxing human FOXN1 variants
Journal of Allergy and Clinical Immunology·2025· 3 cited
22q11.2 Deletion Syndrome Causes a Sox-9–Mediated Expansion of Chondrocytes Limiting Embryonic Thymus Growth Correctable by Minoxidil
Journal of Human Immunity·2025Open Access
Calcium Leaking from the Endoplasmic Reticulum Caused by a Human ITPR3 R2524C Variant Causes Immunodeficiency, Ectodermal Dysplasia, and Charcot-Marie-Tooth Syndrome
Journal of Human Immunity·2025Open Access
The ClinGen Severe Combined Immunodeficiency Disease Variant Curation Expert Panel: Specifications for classification of variants in <i>ADA</i> , <i>DCLRE1C</i> , <i>IL2RG</i> , <i>IL7R</i> , <i>JAK3</i> , <i>RAG1</i> , and <i>RAG2</i>
2025· 1 citedOpen Access
Joint fluid multi-omics improves diagnostic confidence during evaluation of children with presumed septic arthritis
Pediatric Rheumatology·2025· 1 citedOpen Access
Case report: Artificial thymic organoids facilitate clinical decisions for a patient with a TP63 variant and severe persistent T cell lymphopenia
Frontiers in Immunology·2024· 3 citedOpen Access
Joint Fluid Multi-Omics Improves Diagnostic Confidence During Evaluation of Children with Presumed Septic Arthritis
2024Open Access
Oral microbiome related blood borne bacterial DNA signature in toddlers is associated with elevated inflammatory cytokines and anti-viral IgGs
2024Open Access
152 Thymus Hypoplasia in 22q11.2DS (DiGeorge): From Mechanism to Restoration
Clinical Immunology·2024
41 Specifications of ACMG/AMP Variant Curation Guidelines for the Analysis of FOXN1 Sequence Variants: Recommendations by ClinGen’s Severe Combined Immunodeficiency Disease Variant Curation Expert Panel
Clinical Immunology·2024
Comprehensive phenotypic analysis of diverse FOXN1 variants
Journal of Allergy and Clinical Immunology·2023· 18 citedOpen Access
Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome
Journal of Clinical Investigation·2023Open Access
Defining the impact of FOXN1 variants with functional assays and reaggregate thymus organ cultures reveals those with loss- and gain- of function and dominant negative consequences
Clinical Immunology·2023
Thymus Tissue Regeneration in 22q11.2DS Mouse Models (DiGeorge) using Mesenchymal Cell Replacement or Vasodilators
Clinical Immunology·2023
A human ITPR3 variant causes a dominant negative attenuation of calcium responses with immunodeficiency and growth delay confirmed in a mouse model
Clinical Immunology·2023· 3 cited
907 ANA associated regulatory polymorphisms in HLA class III region downregulate complement 4 (C4) gene expression
Genetics·2022Open Access
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Frequent Co-authors

Arthur Weiss(13), Serkan Belkaya(6), Lisa A. Pitcher(6), M. Teresa de la Morena(6), Jennifer A. Young(5), Christoph Wülfing(4), Jennifer L. Eitson(4), Nigel Killeen(3), Qiumei Du(3), Julian D. Watts(3), Ruedi Aebersold(3), H S Teh(3), Laura M. DeFord‐Watts(3), Amy M. Becker(3), Jennifer J. Medeiros(3), Paul E. Love(3), Douglas A. Carlow(3), Hung‐Sia Teh(3), Igor Dozmorov(3), Ashley R. Hoover(3)