Nicolas H. Thomä

École Polytechnique Fédérale de Lausanne — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index11.0kcitations136works6.12yr avg
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Research Topics

Ubiquitin and proteasome pathways(41), Protein Degradation and Inhibitors(32), DNA Repair Mechanisms(28), Genomics and Chromatin Dynamics(17), Cancer-related Molecular Pathways(10)

Publications136 total

The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2
Molecular Cell·2026Open Access
Mapping the latent CRBN-molecular glue degrader interactome
2025Open Access
Gluing the allosteric way
Nature Chemical Biology·2025
E2F1 induces a G0-G1 reentry transcriptional program without changing chromatin accessibility
2025Open Access
Tandem association of CLOCK:BMAL1 complexes on DNA enables recruitment of CBP/p300 through multivalent interactions
2025Open Access
Opportunities in proximity modulation: Bridging academia and industry
Molecular Cell·2025· 2 citedOpen Access
Nucleosomes specify co-factor access to p53
Molecular Cell·2025· 2 citedOpen Access
Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders
Angewandte Chemie·2025Open Access
Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders
Angewandte Chemie International Edition·2025· 9 citedOpen Access
BMAL1 and ARNT enable circadian HIF2α responses in clear cell renal cell carcinoma
Nature Communications·2025· 5 citedOpen Access
Primed for degradation: How weak protein interactions enable molecular glue degraders
Current Opinion in Structural Biology·2025· 8 citedOpen Access
USP7 bound to a nucleosome/p53 complex
2025
A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl Hydrocarbon Receptor Modulation
ACS Central Science·2025· 2 citedOpen Access
Niclosamide: CRL4<sup>AMBRA1</sup> mediated degradation of cyclin D1 following mitochondrial membrane depolarization
RSC Medicinal Chemistry·2025Open Access
Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders
2024
Author Correction: DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Nature Communications·2024· 1 citedOpen Access
BMAL1-HIF2α heterodimers contribute to ccRCC
2024Open Access
Pioneer factors: Emerging rules of engagement for transcription factors on chromatinized DNA
Current Opinion in Structural Biology·2024· 13 citedOpen Access
BMAL1-HIF2α heterodimers contribute to ccRCC
2024· 1 citedOpen Access
Epidemiological trends and susceptibility patterns of bloodstream infections caused by Enterococcus spp. in six German university hospitals: a prospectively evaluated multicentre cohort study from 2016 to 2020 of the R-Net study group
Infection·2024· 12 citedOpen Access
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Frequent Co-authors

Simone Cavadini(13), R.D. Bunker(11), Eric S. Fischer(10), Georg Petzold(7), S. Matsumoto(7), Gondichatnahalli M. Lingaraju(6), Mahamadou Faty(6), Shigenori Iwai(6), Kaoru Sugasawa(6), Zuzanna Kozicka(6), Georg Kempf(6), Daniel Heß(5), Nikola P. Pavletich(5), Dirk Schübeler(5), Andrea Scrima(5), Kirill Alexandrov(5), Ulrich Hassiepen(4), H. Gut(4), Mikołaj Słabicki(4), Wassim Abdulrahman(4)