Michel Sadelain

Columbia University Irving Medical Center — United States

Medicine · Health Sciences

105h-index61.5kcitations644works6.22yr avg
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Research Topics

CAR-T cell therapy research(403), Virus-based gene therapy research(142), Immunotherapy and Immune Responses(105), CRISPR and Genetic Engineering(104), Immune Cell Function and Interaction(97)

Publications643 total

Integrated chronic in vivo and in vitro screens uncover NFIL3 as a driver of T cell dysfunction
Cancer Discovery·2026
Sensitive CAR T cells redefine targetable CD70 expression in solid tumors
Science·2026· 1 cited
Abstract C008: <i>NFIL3</i> emerges as a driver of CAR T cell dysfunction from integrated in vivo/in vitro CRISPR screen
Cancer Immunology Research·2026
CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency
Nature Cancer·2026Open Access
pTα enhances mRNA translation and potentiates CAR T cells for solid tumor eradication
Cell·2025· 1 cited
Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
Nature Aging·2025· 5 citedOpen Access
299 Targeting dysregulated wound healing programs in cancer and fibrosis with immune engineering
Regular and Young Investigator Award Abstracts·2025Open Access
Key considerations for advancing chimeric antigen receptor (CAR) T-cell therapy for systemic lupus erythematosus (SLE): a multi-partner/disciplinary working group perspective
RMD Open·2025Open Access
Abstract PR012: Targeting Chronic Inflammation in Ovarian Cancer Through Immune Engineering
Cancer Research·2025
Zelig Eshhar (1941–2025): a tribute for a life for immunotherapy
Journal for ImmunoTherapy of Cancer·2025Open Access
CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit
Nature Cancer·2025· 14 citedOpen Access
CAR T-cell therapy in SLE: A systematic review
Seminars in Arthritis and Rheumatism·2025· 5 cited
Bispecific killer cell engager-secreting CAR-T cells redirect natural killer specificity to enhance antitumour responses
Nature Biomedical Engineering·2025· 7 cited
POS0813 CAR T-CELL THERAPY IN SLE: A SYSTEMATIC/SCOPING REVIEW
Annals of the Rheumatic Diseases·2025Open Access
Addendum: Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase
Nature Medicine·2025Open Access
Abstract LB024: CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency
Cancer Research·2025
Allogeneic off-the-shelf CAR T-cell therapy for relapsed or refractory B-cell malignancies
Blood Advances·2025· 13 citedOpen Access
HIV immune evasin Nef enhances allogeneic CAR T cell potency
Nature·2025· 13 cited
Results From First-in-Human Phase I Study of a Novel CD19-1XX Chimeric Antigen Receptor With Calibrated Signaling in Large B-Cell Lymphoma
Journal of Clinical Oncology·2025· 9 citedOpen Access
Honing CAR T cells to tackle acute myeloid leukemia
Blood·2024· 28 citedOpen Access
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Frequent Co-authors

Isabelle Rivière(19), Renier J. Brentjens(15), Mithat Gönen(7), Theodoros Giavridis(6), Mohamad Hamieh(6), Eirini P. Papapetrou(5), Jae H. Park(5), Xiuyan Wang(5), Yvette Bernal(5), Justin Eyquem(5), Sjoukje J. C. van der Stegen(5), P. Maslak(4), Marco L. Davila(4), Shirley Bartido(4), Jolanta Stefanski(4), Oriana Bórquez-Ojeda(4), Malgorzata Olszewska(4), Elizabeth Halton(4), Jorge Mansilla‐Soto(4), Raymond Yeh(4)