Derek Yang

Immunology and Microbiology · Life Sciences

27h-index8.8kcitations57works2.62yr avg
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Research Topics

Immune Cell Function and Interaction(16), HIV Research and Treatment(14), T-cell and B-cell Immunology(12), HIV/AIDS drug development and treatment(9), Melanoma and MAPK Pathways(8)

Publications57 total

Population Pharmacokinetic Modeling of Encorafenib and LHY746 In Participants with Solid Tumors in Phase 2 Studies: A Sequential Parent-Metabolite Model
2026Open Access
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC
Nature Communications·2025· 1 citedOpen Access
HIV Virion Capturing Liposomes for Therapeutic Vaccination
2025Open Access
Stoichiometry of HIV-1 envelope glycoprotein protomers with changes that stabilize or destabilize the pretriggered conformation
mBio·2025Open Access
Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants
Journal of Virology·2025Open Access
CD4-mimetics sensitize HIV-infected cells to ADCC mediated by plasma from persons with early-stage HIV-1 infection
Journal of Virology·2025· 2 citedOpen Access
Soluble CD4 inhibits Ebola virus infection by targeting endosomal receptor-binding site
iScience·2025Open Access
Stoichiometry of HIV-1 Envelope Glycoprotein Protomers with Changes That Stabilize or Destabilize the Pretriggered Conformation
2024· 5 citedOpen Access
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity
Journal of Virology·2024· 8 citedOpen Access
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics
Journal of Virology·2024· 10 citedOpen Access
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC
2024· 3 citedOpen Access
NTB-A and 2B4 Natural Killer Cell Receptors Modulate the Capacity of a Cocktail of Non-Neutralizing Antibodies and a Small CD4-Mimetic to Eliminate HIV-1-Infected Cells by Antibody-Dependent Cellular Cytotoxicity
Viruses·2024· 1 citedOpen Access
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity
2024· 4 citedOpen Access
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics
2024· 3 citedOpen Access
V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins
Journal of Virology·2023· 7 citedOpen Access
Pharmacophore variants of the macrocyclic peptide triazole inactivator of HIV-1 Env
Medicinal Chemistry Research·2023· 1 cited
Pharmacophore Variants of the Macrocyclic Peptide Triazole Inactivator of HIV-1 Env
2023Open Access
Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity
Proceedings of the National Academy of Sciences·2023· 26 citedOpen Access
Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity
2023Open Access
VE607 stabilizes SARS-CoV-2 Spike in the “RBD-up” conformation and inhibits viral entry
iScience·2022· 17 citedOpen Access
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Frequent Co-authors

Richard A. Flavell(15), Amos B. Smith(15), Roger J. Davis(12), Jonathan Richard(10), Ta-Jung Chiu(10), Hung-Ching Chen(9), Marzena Pazgier(9), Alan J. Whitmarsh(8), Catherine Bourassa(8), Andrés Finzi(8), Guillaume Beaudoin-Bussières(8), Mehdi Benlarbi(8), Lorie Marchitto(7), Halima Medjahed(7), William D. Tolbert(7), Alexandra Tauzin(6), Étienne Bélanger(6), Songqing Na(5), Joseph Sodroski(5), Katrina Dionne(5)