Lei Xu

Chinese Academy of Tropical Agricultural Sciences — China

Computer Science · Physical Sciences

40h-index8.7kcitations280works3.42yr avg
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Research Topics

Computational Drug Discovery Methods(63), Protein Structure and Dynamics(31), Ubiquitin and proteasome pathways(27), Protein Degradation and Inhibitors(20), PI3K/AKT/mTOR signaling in cancer(15)

Publications278 total

Mechanism-informed identification of FDA-approved topoisomerase inhibitors disrupting SARS-CoV-2 nucleocapsid–RNA interactions
BMC Chemistry·2025Open Access
Synergistic approach utilizing bioinformatics, machine learning, and traditional screening for the identification of novel CSK inhibitors targeting hepatocellular carcinoma
Journal of Computer-Aided Molecular Design·2025
Virtual Screening of HBV Capsid Assembly Modulators with the Combination of Pharmacophore Modeling and Hydrogen Bond Constraints
Medicinal Chemistry·2025
Discovery and Characterization of Novel PIM1 Inhibitors via Virtual Screening and Molecular Dynamics Simulations
ACS Medicinal Chemistry Letters·2025
Effective virtual screening strategy toward JAK3 covalent inhibitors: combining multi‑conformational consensus calculation with covalent docking
Molecular Diversity·2025
A patent review of CHK1 inhibitors (2019 – present)
Expert Opinion on Therapeutic Patents·2025· 1 cited
Screening of triploid in miscarriage tissues using medium-coverage whole genome sequencing with a three-algorithm integrated approach
Journal of Assisted Reproduction and Genetics·2025
Bacillus-loaded biochar as a dual strategy for Fusarium wilt control and soil health improvement in Peanut cultivation
Applied Soil Ecology·2025· 1 cited
Discovery and Characterization of Novel FGFR1 V561M Inhibitors via Virtual Screening and Molecular Dynamics Simulations
ACS Medicinal Chemistry Letters·2025· 2 citedOpen Access
IDDF2025-ABS-0182 Chronic exposure to the nonnutritive sweetener acesulfame-K promotes NAFLD development in a PPARα-dependent manner
2025
A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner
Cell chemical biology·2025· 7 cited
Discovery of Novel c-MET Inhibitors for Hepatocellular Carcinoma Using an Integrated Virtual Screening Approach
ACS Medicinal Chemistry Letters·2025Open Access
A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1
Nature Chemical Biology·2025· 19 cited
Unraveling the Efficacy of AR Antagonists Bearing <i>N</i>-(4-(Benzyloxy)phenyl)piperidine-1-sulfonamide Scaffold in Prostate Cancer Therapy by Targeting LBP Mutations
Journal of Medicinal Chemistry·2025· 1 cited
Anti-MDA5 antibody positive dermatomyositis complicated by interstitial lung disease with an improved outcome: A case report
Medicine·2025Open Access
Prenatal Diagnosis of Foetal Structural Anomalies Using Medium‐Coverage Whole Genome Sequencing (<scp>CMA</scp>‐Seq): A Large‐Scale Comparative Study With <scp>CMA</scp> in 3973 Pregnancies
BJOG An International Journal of Obstetrics & Gynaecology·2025
Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity
Journal of Enzyme Inhibition and Medicinal Chemistry·2025· 2 citedOpen Access
Astragalus polysaccharide alleviates oxidative stress and senescence in chondrocytes in osteoarthritis via GCN2/ATF4/TXN axis
International Journal of Biological Macromolecules·2025· 5 cited
Corrigendum to “Unveiling the biological variation of lymphocyte subset counts: Insights from a full-spectrum flow cytometer and the BD Multitest™ 6-Color TBNK kit” [Clin. Chim. Acta 569 (2025) 120152]
Clinica Chimica Acta·2025
The Utilization of Machine Learning Approaches in Predicting the Prominent Physicochemical Properties of Polychlorinated Biphenyl
International Journal of Pattern Recognition and Artificial Intelligence·2025
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Frequent Co-authors

Tingjun Hou(26), Youyong Li(12), Huiyong Sun(11), Chao Shen(9), Yu Kang(8), Zhe Wang(7), Sheng Tian(7), Peichen Pan(6), Dan Li(5), Dongsheng Cao(5), Xujun Zhang(5), Jia Li(5), Dan Li(4), Ercheng Wang(4), Sudan He(3), Di Zhu(3), Fan Wu(3), Boshun Wan(3), Jinping Pang(3), Haiyang Zhong(3)