Ian E. Alexander

University of Sydney — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

51h-index14.0kcitations247works7.62yr avg
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Research Topics

Virus-based gene therapy research(130), CRISPR and Genetic Engineering(66), RNA Interference and Gene Delivery(45), CAR-T cell therapy research(25), Viral gastroenteritis research and epidemiology(21)

Publications247 total

Exploration of the potential of genomic editing in the treatment of congenital adrenal hyperplasia
Frontiers in Endocrinology·2025Open Access
Targeted editing of the 21-hydroxylase locus confers durable therapeutic effect in a murine model of congenital adrenal hyperplasia
Molecular Therapy·2025· 1 citedOpen Access
Pancreatic transdifferentiation of NOD mouse livers prevented development of hyperglycemia
Molecular Therapy·2025· 1 citedOpen Access
Highly Efficient Functional Editing of the Native Ornithine Transcarbamylase Locus by Targeted Integration with Phenotype Correction and Restoration of Physiological Patterns of Gene Expression
2025Open Access
High-throughput evaluation of cardiac-specific promoters for adeno-associated virus mediated cardiac gene therapy
Gene Therapy·2025· 2 citedOpen Access
Gene therapy enhances deoxyribonuclease I treatment in antimyeloperoxidase glomerulonephritis
JCI Insight·2025· 1 citedOpen Access
AAV-mHDM-FH: Safety and expression profile in two murine models of hyper-complement activation
Immunobiology·2025· 1 citedOpen Access
07-8: ENGINEERING ISLETS FOR TOLERANCE WITH PROTECTIVE GENES: UPDATE ON A FIRST IN HUMAN SAFETY STUDY WITH BABS-AAV2-A20
Transplantation·2025
Towards durable genomic editing for the treatment of congenital adrenal hyperplasia
Endocrine Abstracts·2025
Structural characterization of antibody-responses following Zolgensma treatment for AAV capsid engineering to expand patient cohorts
Nature Communications·2025· 8 citedOpen Access
AAVolve: Concatenated long-read deep sequencing enables whole capsid tracking during shuffled AAV library selection
Molecular Therapy — Methods & Clinical Development·2024· 2 citedOpen Access
Treatment of anti-myeloperoxidase glomerulonephritis using recombinant deoxyribonuclease I is enhanced by adeno-associated virus gene therapy
2024Open Access
Gene therapy clinical trials worldwide to 2023—an update
The Journal of Gene Medicine·2024· 59 cited
Stable transduction of the neonatal mouse liver using a hybrid rAAV/<i>sleeping beauty</i> transposon gene delivery system
The Journal of Gene Medicine·2024Open Access
Genome editing in the adrenal gland: a novel strategy for treating congenital adrenal hyperplasia
Exploration of Endocrine and Metabolic Diseases·2024· 3 citedOpen Access
Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency
Molecular Therapy·2024· 17 citedOpen Access
Structural characterization of antibody-responses from Zolgensma treatment provides the blueprint for the engineering of an AAV capsid suitable for redosing
2024· 3 citedOpen Access
Liver-specific adiponectin gene therapy suppresses microglial NLRP3-inflammasome activation for treating Alzheimer’s disease
Journal of Neuroinflammation·2024· 22 citedOpen Access
Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation
Nature Communications·2024· 24 citedOpen Access
AAV-delivered hepato-adrenal cooperativity in steroidogenesis: Implications for gene therapy for congenital adrenal hyperplasia
Molecular Therapy — Methods & Clinical Development·2024· 7 citedOpen Access
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Frequent Co-authors

Samantha L. Ginn(9), Leszek Lisowski(8), Sharon C. Cunningham(8), David W. Russell(8), A. Dusty Miller(8), Allison Dane(6), Adrian J. Thrasher(5), Grant J. Logan(4), Erhua Zhu(4), John Shine(4), Marina Cavazzana(3), Michael Edelstein(3), Michelle A. Farrar(3), Christine L. Clarke(3), Robert L. Sutherland(3), Sophia H.Y. Liao(3), Marti Cabanes‐Creus(3), Christof von Kalle(2), Manfred Schmidt(2), Éric Delabesse(2)