Vita S. Brawley

Medicine · Health Sciences

16h-index4.1kcitations33works0.02yr avg
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Research Topics

CAR-T cell therapy research(24), Immunotherapy and Immune Responses(13), Monoclonal and Polyclonal Antibodies Research(4), Nanowire Synthesis and Applications(4), Advancements in Semiconductor Devices and Circuit Design(3)

Publications27 total

Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
Journal of Clinical Investigation·2021· 18 citedOpen Access
HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial
UNC Libraries·2020· 68 citedOpen Access
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
Journal of Clinical Investigation·2019· 28 citedOpen Access
Expansion of HER2-CAR T cells after lymphodepletion and clinical responses in patients with advanced sarcoma.
Journal of Clinical Oncology·2017· 41 cited
HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma
JAMA Oncology·2017· 807 citedOpen Access
Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape
Journal of Clinical Investigation·2016· 657 citedOpen Access
A Bispecific Chimeric Antigen Receptor Molecule Enhances the Anti-Glioblastoma Efficacy of T Cells Through Dual Immunological Synapse Formation
Cytotherapy·2016
A bispecific chimeric antigen receptor molecule enhances T cell activation through dual immunological synapse formation and offsets antigen escape in glioblastoma
Journal for ImmunoTherapy of Cancer·2015· 8 citedOpen Access
Autologous HER2 CMV bispecific CAR T cells are safe and demonstrate clinical benefit for glioblastoma in a Phase I trial.
Journal for ImmunoTherapy of Cancer·2015· 61 citedOpen Access
Autologous HER2 CMV bispecific CAR T cells for progressive glioblastoma: Results from a phase I clinical trial.
Journal of Clinical Oncology·2015· 9 cited
19. A Phase I Clinical Trial of Autologous HER2 CMV Bispecific CAR T Cells for Progressive Glioblastoma
Molecular Therapy·2015· 1 citedOpen Access
Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma
Journal of Clinical Oncology·2015· 959 citedOpen Access
Abstract B8: Adoptive immunotherapy targeting tumor heterogeneity in high-grade glioma (HGG)
Cancer Research·2014
Erratum to: Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme
Journal of Neuro-Oncology·2014· 1 citedOpen Access
Genetic modification of T cells with a novel bispecific chimeric antigen receptor to enhance the control of high-grade glioma (HGG).
Journal of Clinical Oncology·2014· 9 cited
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme
Journal of Neuro-Oncology·2014· 30 citedOpen Access
A bispecific chimeric antigen receptor targeting antigen escape variants in glioblastoma
Cytotherapy·2014· 1 cited
The miR-223/Nuclear Factor I-A Axis Regulates Glial Precursor Proliferation and Tumorigenesis in the CNS
Journal of Neuroscience·2013· 54 citedOpen Access
Combinational Targeting Offsets Antigen Escape and Enhances Effector Functions of Adoptively Transferred T Cells in Glioblastoma
Molecular Therapy·2013· 367 citedOpen Access
Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells
Clinical Immunology·2013· 64 citedOpen Access
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Frequent Co-authors

Nabil Ahmed(27), Stephen Gottschalk(21), Meenakshi Hegde(17), Helen E. Heslop(15), Winfried S. Wels(15), Tiara T. Byrd(13), Gianpietro Dotti(12), Zakaria Grada(11), Alexia Ghazi(10), Malcolm K. Brenner(10), Kevin Bielamowicz(10), Amanda Wakefield(10), Hao Liu(9), Cliona M. Rooney(9), Yvonne Kew(9), Suzanne Z. Powell(9), Kevin Chow(9), Aidin Ashoori(8), John Hicks(8), Adrian P. Gee(8)