Zhenning He

Fudan University — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.4kcitations28works3.02yr avg
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Research Topics

Virus-based gene therapy research(13), CRISPR and Genetic Engineering(10), Hemoglobinopathies and Related Disorders(8), Iron Metabolism and Disorders(4), RNA Interference and Gene Delivery(4)

Publications28 total

IDO1-mediated AhR activation up-regulates pentose phosphate pathway via NRF2 to inhibit ferroptosis in lung cancer
Biochemical Pharmacology·2025· 3 cited
Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration
Nature Biotechnology·2023· 119 citedOpen Access
Loss of transgene expression limits liver gene therapy in primates
2022· 10 citedOpen Access
Prednisolone reduces the interferon response to AAV in cynomolgus macaques and may increase liver gene expression
Molecular Therapy — Methods & Clinical Development·2022· 22 citedOpen Access
Developing a second-generation clinical candidate AAV vector for gene therapy of familial hypercholesterolemia
Molecular Therapy — Methods & Clinical Development·2021· 23 citedOpen Access
Long-term stable reduction of low-density lipoprotein in nonhuman primates following in vivo genome editing of PCSK9
Molecular Therapy·2021· 55 citedOpen Access
A mutation-independent CRISPR-Cas9–mediated gene targeting approach to treat a murine model of ornithine transcarbamylase deficiency
Science Advances·2020· 65 citedOpen Access
CRISPR/Cas9-mediated in vivo gene targeting corrects hemostasis in newborn and adult factor IX–knockout mice
Blood·2019· 83 citedOpen Access
Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol
Nature Biotechnology·2018· 122 cited
AAV gene therapy corrects OTC deficiency and prevents liver fibrosis in aged OTC-knock out heterozygous mice
Molecular Genetics and Metabolism·2017· 51 citedOpen Access
Strategies for Selection of AAV Vectors for Administration to Liver: Studies in Nonhuman Primates
Blood·2016· 1 cited
Effects of Self-Complementarity, Codon Optimization, Transgene, and Dose on Liver Transduction with AAV8
Human Gene Therapy Methods·2016· 25 citedOpen Access
481. CRISPR/Cas9-Mediated In Vivo Genome Editing to Correct the OTC spfash Mutation in Newborn Mice
Molecular Therapy·2016
227. A Dose-Escalating Preclinical Study to Determine the Efficacy, MED, and Safety of a Clinical Candidate Vector in a Mouse Model of Hemophilia B
Molecular Therapy·2016Open Access
A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice
Nature Biotechnology·2016· 552 citedOpen Access
Comparative Study of Liver Gene Transfer With AAV Vectors Based on Natural and Engineered AAV Capsids
Molecular Therapy·2015· 103 citedOpen Access
174. Liver Fibrosis in Aged OTC-KO Heterozygotes and Successful Correction by AAV8-Mediated Gene Therapy
Molecular Therapy·2015Open Access
Structural determinants of human ζ-globin mRNA stability
Journal of Hematology & Oncology·2014· 4 citedOpen Access
Structure of fully liganded Hb ζ<sub>2</sub>β<sub>2</sub><sup>s</sup>trapped in a tense conformation
Acta Crystallographica Section D Biological Crystallography·2013· 6 citedOpen Access
Dynamic posttranscriptional regulation of ϵ-globin gene expression in vivo
Blood·2006· 5 citedOpen Access
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Frequent Co-authors

Lili Wang(16), James M. Wilson(16), Peter Bell(14), John White(10), Janice Russell(9), Hongwei Yu(7), Deirdre McMenamin(6), Camilo Breton(6), Hiroki Morizono(5), Mark L. Batshaw(5), Yanqing Zhu(5), Yang Yang(4), Chenyu Xu(3), Yan Che(3), Roberto Calcedo(3), Elizabeth L. Buza(3), A. Saveliev(3), John W. White(3), Tamara Goode(3), Mingyao Li(3)