Roberto Calcedo

Johns Hopkins University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index10.7kcitations111works47.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Virus-based gene therapy research(80), Viral gastroenteritis research and epidemiology(21), RNA Interference and Gene Delivery(18), Herpesvirus Infections and Treatments(17), CAR-T cell therapy research(15)

Publications111 total

Intrathecal Gene Therapy for Giant Axonal Neuropathy
New England Journal of Medicine·2024· 47 citedOpen Access
Prednisolone and rapamycin reduce the plasma cell gene signature and may improve AAV gene therapy in cynomolgus macaques
Gene Therapy·2023· 8 citedOpen Access
MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates
Science Translational Medicine·2020· 159 cited
An Open Resource for Non-human Primate Optogenetics
Neuron·2020· 123 citedOpen Access
Isolating Human Monoclonal Antibodies Against Adeno-Associated Virus From Donors With Pre-existing Immunity
Frontiers in Immunology·2020· 7 citedOpen Access
Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial
Molecular Therapy·2020· 48 citedOpen Access
Susceptibility to SIV Infection After Adenoviral Vaccination in a Low Dose Rhesus Macaque Challenge Model
Pathogens and Immunity·2019· 3 citedOpen Access
AAV8 Gene Therapy for Crigler-Najjar Syndrome in Macaques Elicited Transgene T Cell Responses That Are Resident to the Liver
Molecular Therapy — Methods & Clinical Development·2018· 17 citedOpen Access
Toxicology Study of Intra-Cisterna Magna Adeno-Associated Virus 9 Expressing Human Alpha-L-Iduronidase in Rhesus Macaques
Molecular Therapy — Methods & Clinical Development·2018· 101 citedOpen Access
Toxicology Study of Intra-Cisterna Magna Adeno-Associated Virus 9 Expressing Iduronate-2-Sulfatase in Rhesus Macaques
Molecular Therapy — Methods & Clinical Development·2018· 81 citedOpen Access
Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol
Nature Biotechnology·2018· 122 cited
Optimized Adeno-Associated Viral-Mediated Human Factor VIII Gene Therapy in Cynomolgus Macaques
Human Gene Therapy·2018· 22 citedOpen Access
Assessment of humoral, innate, and T-cell immune responses to adeno-associated virus vectors
Human Gene Therapy Methods·2018· 4 cited
Assessment of Humoral, Innate, and T-Cell Immune Responses to Adeno-Associated Virus Vectors
Human Gene Therapy Methods·2018· 61 cited
Immune Responses in 101HEMB01, a Phase 1/2 Open-Label, Single Ascending Dose-Finding Trial of DTX101 (AAVrh10FIX) in Patients with Severe Hemophilia B
Blood·2017· 10 cited
Safety and Efficacy of AAV5 Vectors Expressing Human or Canine CNGB3 in <i>CNGB3</i> -Mutant Dogs
Human Gene Therapy Clinical Development·2017· 29 citedOpen Access
5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency
Molecular Therapy·2017· 105 citedOpen Access
Nonclinical Pharmacology/Toxicology Study of AAV8.TBG.mLDLR and AAV8.TBG.hLDLR in a Mouse Model of Homozygous Familial Hypercholesterolemia
Human Gene Therapy Clinical Development·2017· 39 citedOpen Access
Non-Clinical Study Examining AAV8.TBG.hLDLR Vector-Associated Toxicity in Chow-Fed Wild-Type and LDLR <sup>+/−</sup> Rhesus Macaques
Human Gene Therapy Clinical Development·2017· 52 citedOpen Access
Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency
Proceedings of the National Academy of Sciences·2017· 82 citedOpen Access
page 1 of 6Next →

Frequent Co-authors

James M. Wilson(46), Lili Wang(18), Guangping Gao(15), Peter Bell(15), Luk H. Vandenberghe(12), Rebecca Grant(9), Suryanarayan Somanathan(8), Jianping Lin(6), Terence R. Flotte(6), Jeffrey D. Chulay(6), Joanita Figueredo(6), Margaret Humphries(5), Christian Mueller(5), You Lü(4), Farshid N. Rouhani(4), Julio Sanmiguel(4), Elizabeth L. Buza(4), Soumitra Roy(4), Mauricio R. Alvira(3), Julie Johnston(3)