Erin Bote

University of Pennsylvania — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

6h-index480citations12works0.02yr avg
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Research Topics

Virus-based gene therapy research(10), Retinal Development and Disorders(4), Herpesvirus Infections and Treatments(3), RNA Interference and Gene Delivery(3), Retinal and Optic Conditions(3)

Publications12 total

AAV8 Gene Therapy for Crigler-Najjar Syndrome in Macaques Elicited Transgene T Cell Responses That Are Resident to the Liver
Molecular Therapy — Methods & Clinical Development·2018· 17 citedOpen Access
Safety of the Subretinal Delivery of RGX-314 AAV8-anti-VEGF Fab Gene Therapy in NHP: Retinal Structure Over One Year
Investigative Ophthalmology & Visual Science·2018· 2 citedOpen Access
Safety of subretinal delivery of RGX-314 (AAV8-anti-VEGF Fab) in the non-human primate as assessed by full-field ERG
Investigative Ophthalmology & Visual Science·2018· 1 citedOpen Access
Optimized Adeno-Associated Viral-Mediated Human Factor VIII Gene Therapy in Cynomolgus Macaques
Human Gene Therapy·2018· 22 citedOpen Access
Evaluation of Intrathecal Routes of Administration for Adeno-Associated Viral Vectors in Large Animals
Human Gene Therapy·2017· 146 citedOpen Access
Normal parameters of the full field ERG recorded with bipolar electrodes in Cynomolgus Macaque (Macaque fascicularis)
Investigative Ophthalmology & Visual Science·2017· 1 citedOpen Access
Subretinal delivery of RGX-314 AAV8-anti-VEGF Fab gene therapy in NHP
Investigative Ophthalmology & Visual Science·2017· 2 citedOpen Access
760. Optimized AAV-Mediated Human Factor VIII Gene Therapy in Hemophilia A Mice and Cynomolgus Macaques
Molecular Therapy·2016· 1 citedOpen Access
Impact of intravenous infusion time on AAV8 vector pharmacokinetics, safety, and liver transduction in cynomolgus macaques
Molecular Therapy — Methods & Clinical Development·2016· 17 citedOpen Access
Motor Neuron Transduction After Intracisternal Delivery of AAV9 in a Cynomolgus Macaque
Human Gene Therapy Methods·2015· 6 cited
Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna
Molecular Therapy — Methods & Clinical Development·2014· 129 citedOpen Access
Safety and Efficacy of Subretinal Readministration of a Viral Vector in Large Animals to Treat Congenital Blindness
Science Translational Medicine·2010· 136 citedOpen Access

Frequent Co-authors

James M. Wilson(10), Peter Bell(5), Tamara Goode(5), Albert M. Maguire(5), Jean Bennett(5), Leah Makaron(5), Jenny A. Greig(4), Arkady Lyubarsky(4), Erik Wielechowski(4), Gui‐Shuang Ying(4), Tomás S. Alemán(4), Christian Hinderer(3), Jean‐Pierre Louboutin(3), Hongwei Yu(3), Rebecca Grant(3), Jayme M.L. Nordin(3), Anna Tretiakova(3), Charles H. Vite(2), Roberto Calcedo(2), Samuel C. Wadsworth(2)