Matthias T. Stephan

Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa — South Africa

Medicine · Health Sciences

19h-index5.0kcitations49works5.42yr avg
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Research Topics

CAR-T cell therapy research(27), Immunotherapy and Immune Responses(18), Immune Cell Function and Interaction(11), RNA Interference and Gene Delivery(10), Virus-based gene therapy research(7)

Publications49 total

Drinkable gene therapy foam for the treatment of constrictive esophageal carcinoma
Gene Therapy·2026Open Access
The dawn of in vivo immune cell engineering in oncology
Nature Biotechnology·2026
Bedside manufacturing of engineered stem cells using gene therapy foam
Molecular Therapy — Methods & Clinical Development·2025Open Access
In vivo chimeric antigen receptor (CAR)-T cell therapy
Nature Reviews Drug Discovery·2025· 16 cited
Liquid foam improves potency and safety of gene therapy vectors
Nature Communications·2024· 8 citedOpen Access
Biomaterial-based scaffolds for direct in situ programming of tumor-infiltrating T lymphocytes
Journal of Controlled Release·2024· 13 cited
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection
Nature Medicine·2024· 1 citedOpen Access
BiTE secretion from in situ-programmed myeloid cells results in tumor-retained pharmacology
Journal of Controlled Release·2021· 13 citedOpen Access
Genetic in situ engineering of myeloid regulatory cells controls inflammation in autoimmunity
Journal of Controlled Release·2021· 11 citedOpen Access
Empowering patients from within: Emerging nanomedicines for in vivo immune cell reprogramming
Seminars in Immunology·2021· 13 citedOpen Access
In Situ Programming of CAR T Cells
Annual Review of Biomedical Engineering·2021· 61 citedOpen Access
In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
Nature Communications·2020· 380 citedOpen Access
Nitinol thin films functionalized with CAR-T cells for the treatment of solid tumours
Nature Biomedical Engineering·2019· 108 cited
Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers
Nature Communications·2019· 487 citedOpen Access
Abstract 4770: Programming tumor-clearing macrophages with targeted in situ gene therapy
Experimental and Molecular Therapeutics·2019
Abstract 4770: Programming tumor-clearing macrophages with targeted in situ gene therapy
Cancer Research·2019
Abstract IA07: Genetic engineering of therapeutic T cells using synthetic nanoparticles
Cancer Immunology Research·2018
Nanoparticles That Reshape the Tumor Milieu Create a Therapeutic Window for Effective T-cell Therapy in Solid Malignancies
Cancer Research·2018· 126 citedOpen Access
Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers
Nature Communications·2017· 170 citedOpen Access
Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors
Journal of Clinical Investigation·2017· 329 citedOpen Access
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Frequent Co-authors

Sirkka B. Stephan(16), Darrell J. Irvine(8), Michel Sadelain(8), Neha N. Parayath(6), Renier J. Brentjens(5), Tyrel T. Smith(4), Howell Moffett(4), Smitha P.S. Pillai(4), Alex H. Chang(4), Soong Ho Um(3), Anna Bershteyn(3), Fan Zhang(3), Amanda Koehne(3), Michael Coon(3), S. Annie Gai(3), Katelyn Fitzgerald(3), James J. Moon(2), Laura E. McKnight(2), Chibawanye Ene(2), Eric C. Holland(2)