Shuchi Agrawal‐Singh

Wellcome/MRC Cambridge Stem Cell Institute — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index1.6kcitations32works2.82yr avg
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Research Topics

Epigenetics and DNA Methylation(16), Acute Myeloid Leukemia Research(11), Cancer-related gene regulation(11), Histone Deacetylase Inhibitors Research(9), Genomics and Chromatin Dynamics(7)

Publications32 total

CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition
Nature Communications·2025· 5 citedOpen Access
Delayed Trp53 activation protects Dnmt3a-mutant hematopoietic stem cells from inflammatory attrition.
2025
Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation
Blood·2024· 12 citedOpen Access
Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation
Blood·2024Open Access
Delayed Trp53 Activation Protects <i>Dnmt3a</i>-Mutant Haematopoietic Stem Cells from Inflammatory Attrition
Blood·2024Open Access
Abstract 363: Genetic or pharmacological inactivation of CREBBP sensitizes B-cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition
Cancer Research·2024
A guide to epigenetics in leukaemia stem cells
Molecular Oncology·2023· 4 citedOpen Access
Genetic or pharmacological inactivation of CREBBP sensitizes B-cell Acute Lymphoblastic Leukemia to Ferroptotic Cell Death upon BCL2 Inhibition
2023Open Access
HOXA9 forms a repressive complex with nuclear matrix–associated protein SAFB to maintain acute myeloid leukemia
Blood·2022· 13 citedOpen Access
HOXA9 Nucleates a Repressive Chromatin Complex with Nuclear Matrix-Associated Protein- Safb to Maintain Acute Myeloid Leukemia
Blood·2022
HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia
2022· 1 citedOpen Access
Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activation
2022Open Access
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression
Nature Genetics·2021· 36 citedOpen Access
Mutational synergy coordinately remodels chromatin accessibility, enhancer landscape and 3-Dimensional DNA topology to alter gene expression during leukemia induction
2020Open Access
Mutational Synergy Coordinately Remodels Chromatin Accessibility, Enhancer Landscape and 3-Dimensional DNA Topology to Alter Gene Expression during Leukemia Induction
Blood·2019· 3 cited
Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6
Proceedings of the National Academy of Sciences·2019· 74 citedOpen Access
PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells
eLife·2019· 51 citedOpen Access
Author response: PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells
2018Open Access
Author response: PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells
2018Open Access
Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia
Nature Medicine·2016· 252 citedOpen Access
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Frequent Co-authors

Brian J.P. Huntly(15), George Giotopoulos(14), Sarah J. Horton(14), Klaus Hansen(13), Carsten Müller‐Tidow(11), Eshwar Meduri(10), Mads Lerdrup(9), Wolfgang E. Berdel(9), Haiyang Yun(9), Daniel Sasca(9), Jaana Bagri(9), Hans‐Ulrich Klein(7), Hubert Serve(7), Martin Dugas(7), George S. Vassiliou(7), Dhoyazan Azazi(7), Christian Thiede(6), Faisal Basheer(6), Paolo Gallipoli(6), Kristian Helin(5)