Holger Cynis

Fraunhofer Institute for Cell Therapy and Immunology — Germany

Medicine · Health Sciences

26h-index2.7kcitations79works2.72yr avg
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Research Topics

Alzheimer's disease research and treatments(35), Amino Acid Enzymes and Metabolism(20), Neuroscience and Neuropharmacology Research(11), Glycosylation and Glycoproteins Research(10), Neuroinflammation and Neurodegeneration Mechanisms(8)

Publications79 total

Automatic pain face analysis in mice: Applied to a varied dataset with non-standardized conditions
2026Open Access
Mouse Grimace Faces Dataset
Technische Universität Berlin – Universitätsbibliothek·2026Open Access
Search for factors that inhibit expression of endogenous retroviruses
Klinische Pädiatrie·2025
Infection-Specific Reprogramming of Microglia Reveals Distinct Virulence Pathways Linking Periodontal Pathogens to Alzheimer’s Disease
2025Open Access
3D-printed microstructured alginate scaffolds for neural tissue engineering
Trends in biotechnology·2024· 18 citedOpen Access
Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity
Antiviral Research·2024· 3 citedOpen Access
Dipeptidyl peptidase 4 deficiency improves survival after focal cerebral ischemia in mice and ameliorates microglia activation and specific inflammatory markers
Neurobiology of Disease·2024· 1 citedOpen Access
Focal Cerebral Ischemia Induces Expression of Glutaminyl Cyclase along with Downstream Molecular and Cellular Inflammatory Responses
Cells·2024Open Access
Identification of isoaspartate-modified transthyretin as potential target for selective immunotherapy of transthyretin amyloidosis
Amyloid·2024· 1 citedOpen Access
Three dimensionally printed microstructured alginate scaffolds for neural tissue engineering
2024Open Access
Consequences of Amyloid‐β Deficiency for the Liver
Advanced Science·2024· 7 citedOpen Access
A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
Alzheimer s Research & Therapy·2023· 17 citedOpen Access
Immunogenicity of the Envelope Surface Unit of Human Endogenous Retrovirus K18 in Mice
International Journal of Molecular Sciences·2022· 2 citedOpen Access
Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice
Biomolecules·2022· 7 citedOpen Access
Combinational therapy, concomitantly targeting post‐translational modified Aβ peptides and CD33, leads to an add‐on effect in passive immunotherapy
Alzheimer s & Dementia·2021
Identification of Differentially Expressed Human Endogenous Retrovirus Families in Human Leukemia and Lymphoma Cell Lines and Stem Cells
Frontiers in Oncology·2021· 20 citedOpen Access
Endogenous Retroviral–K Envelope Is a Novel Tumor Antigen and Prognostic Indicator of Renal Cell Carcinoma
Frontiers in Oncology·2021· 22 citedOpen Access
Endogenous Retroviruses in Nervous System Disorders
Pharmaceuticals·2021· 34 citedOpen Access
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life
Nature Neuroscience·2020· 78 citedOpen Access
Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer’s disease-like pathology
Alzheimer s Research & Therapy·2020· 19 citedOpen Access
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Frequent Co-authors

Hans‐Ulrich Demuth(24), Stephan Schilling(22), Steffen Roßner(16), Torsten Hoffmann(10), Michael Wermann(9), Stephan Schilling(9), Astrid Kehlen(8), Maike Hartlage‐Rübsamen(8), Sigrid Graubner(7), Ulrich Heiser(7), Alexander Waniek(7), Jens‐Ulrich Rahfeld(7), Stefanie Geißler(7), Wolfgang Jagla(6), Birgit Koch(6), Markus Morawski(5), Reinhard Sedlmeier(5), Stephan von Hörsten(5), Rico Eichentopf(5), Hans‐Ulrich Demuth(5)