Kevin Eggan

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

74h-index29.5kcitations255works10.82yr avg
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Research Topics

Pluripotent Stem Cells Research(110), CRISPR and Genetic Engineering(73), Amyotrophic Lateral Sclerosis Research(49), Neurogenetic and Muscular Disorders Research(32), Reproductive Biology and Fertility(26)

Publications253 total

Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues
Cell·2025· 1 cited
The Specification and Functional Maturation of Sub-Cerebral Projection Neurons Derived from Human Induced Pluripotent Stem Cells
Stem Cells and Development·2025Open Access
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD
Nature Neuroscience·2025· 5 citedOpen Access
Dynamic changes in chromosome and nuclear architecture during maturation of normal and ALS C9orf72 motor neurons
2025· 1 citedOpen Access
Recombinant Adeno-Associated Virus Integration Profiles in Nonhuman Primates and Gene Therapy Participants after Treatment with Valoctocogene Roxaparvovec
Human Gene Therapy·2025· 1 citedOpen Access
C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7
Acta Neuropathologica Communications·2025· 4 citedOpen Access
KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons
Neurobiology of Disease·2024· 8 citedOpen Access
KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons
2024· 3 citedOpen Access
735 Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
Journal of Investigative Dermatology·2024· 1 cited
Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS
Nature Aging·2024· 29 citedOpen Access
CSMD1 regulates brain complement activity and circuit development
Brain Behavior and Immunity·2024· 37 citedOpen Access
Protocol for neurogenin-2-mediated induction of human stem cell-derived neural progenitor cells
STAR Protocols·2024· 6 citedOpen Access
Myeloid and lymphoid expression of <i>C9orf72</i> regulates IL-17A signaling in mice
Science Translational Medicine·2024· 13 citedOpen Access
High-dimensional phenotyping to define the genetic basis of cellular morphology
Nature Communications·2024· 45 citedOpen Access
Downregulation of the silent potassium channel Kv8.1 increases motor neuron vulnerability in amyotrophic lateral sclerosis
Brain Communications·2024· 8 citedOpen Access
Biallelic loss-of-function variants in CACHD1 cause a novel neurodevelopmental syndrome with facial dysmorphism and multisystem congenital abnormalities
Genetics in Medicine·2023· 8 citedOpen Access
Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
Cell Reports Medicine·2023· 1 citedOpen Access
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro
Nature Immunology·2023· 138 citedOpen Access
Reprogramming method does not impact the neuronal differentiation potential of 16p11.2 deletion patient iPSCs
2023· 1 citedOpen Access
Downregulation of the silent potassium channel Kv8.1 increases ALS motor neuron vulnerability
2023Open Access
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Frequent Co-authors

Rudolf Jaenisch(9), Evangelos Kiskinis(8), Hidenori Akutsu(7), Brian J. Wainger(7), Ryuzo Yanagimachi(6), Gabriella L. Boulting(5), Justin K. Ichida(5), Dieter Egli(5), William M. Rideout(5), Luis A. Williams(5), Clifford J. Woolf(5), Florian T. Merkle(5), Kathy K. Niakan(4), Alexander Meissner(4), Konrad Hochedlinger(4), Steve S.W. Han(4), Sulagna Ghosh(4), John T. Dimos(3), Gist F. Croft(3), Hynek Wichterle(3)