Konrad Hochedlinger

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

83h-index40.0kcitations190works5.02yr avg
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Research Topics

Pluripotent Stem Cells Research(115), CRISPR and Genetic Engineering(79), Renal and related cancers(39), Epigenetics and DNA Methylation(33), Genomics and Chromatin Dynamics(18)

Publications190 total

Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration
Nature Communications·2026Open Access
Metformin inhibits nuclear egress of chromatin fragments in senescence and aging
Nature Aging·2026
Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs
Cell stem cell·2025· 4 cited
Bivalent chromatin instructs lineage specification during hematopoiesis
Cell·2025· 8 cited
Hematopoietic stem cells undergo bidirectional fate transitions <i>in vivo</i>
2025· 2 citedOpen Access
Manipulating cell fate through reprogramming: approaches and applications
Development·2024· 10 citedOpen Access
A cellular identity crisis? Plasticity changes during aging and rejuvenation
Genes & Development·2024· 9 citedOpen Access
Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks
Stem Cell Reports·2024· 9 citedOpen Access
Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome
Life Science Alliance·2024· 3 citedOpen Access
H3K36 methylation maintains cell identity by regulating opposing lineage programmes
Nature Cell Biology·2023· 35 citedOpen Access
Morphomechanic tuning of ERK by actin-TFII-IΔ regulates cell identity
2023· 1 citedOpen Access
Correction: Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis
Oncogene·2023Open Access
Data from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
2023Open Access
Supp Methods from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
2023Open Access
Data from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
2023Open Access
Supp tables 1-5 from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
2023Open Access
Supp tables 1-5 from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
2023Open Access
Supp Figs 1-5 from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
2023Open Access
Supp Methods from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
2023Open Access
Supp Figs 1-5 from Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
2023Open Access
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Frequent Co-authors

Rudolf Jaenisch(17), Matthias Stadtfeld(14), Nimet Maherali(11), Jochen Utikal(6), Effie Apostolou(6), José M. Polo(5), George Q. Daley(4), Sarah Eminli(4), Toshi Shioda(4), Ryan Walsh(4), Hidenori Akutsu(4), Kevin Eggan(4), Marius Wernig(3), Tim Ahfeldt(3), Katrin Arnold(3), Kathrin Plath(3), Warakorn Kulalert(3), Sridaran Natesan(3), Justin Brumbaugh(3), William M. Rideout(3)