Alex T. Kalinka

AstraZeneca (United Kingdom) — United Kingdom

Agricultural and Biological Sciences · Life Sciences

17h-index2.0kcitations31works2.22yr avg
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Research Topics

Animal Behavior and Reproduction(6), CRISPR and Genetic Engineering(5), Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities(4), Genetics and Neurodevelopmental Disorders(4), Advanced biosensing and bioanalysis techniques(3)

Publications31 total

The genetic and biochemical basis of human leading strand synthesis
Nature Communications·2025Open Access
Controlling False Discovery in CRISPR Screens
2025· 1 citedOpen Access
A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency
BMC Genomics·2025· 9 citedOpen Access
A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency
2024· 1 citedOpen Access
Abstract 2945: Using pooled minimal genome-wide sgRNA libraries to drive oncology drug discovery
Cancer Research·2024
Androgens increase excitatory neurogenic potential in human brain organoids
Nature·2022· 111 citedOpen Access
Male sex hormones increase excitatory neuron production in developing human neocortex
2020· 3 citedOpen Access
Improving the sensitivity of differential-expression analyses for under-powered RNA-seq experiments
2020· 2 citedOpen Access
The genetics of egg retention and fertilization success in<i>Drosophila</i>: One step closer to understanding the transition from facultative to obligate viviparity
Evolution·2017· 25 cited
Effects of larval crowding on quantitative variation for development time and viability in <i>Drosophila melanogaster</i>
Ecology and Evolution·2016· 38 citedOpen Access
A novel method for quantifying the rate of embryogenesis uncovers considerable genetic variation for the duration of embryonic development in Drosophila melanogaster
BMC Evolutionary Biology·2016· 21 citedOpen Access
Comment on “Cortical folding scales universally with surface area and thickness, not number of neurons”
Science·2016· 17 citedOpen Access
How did viviparity originate and evolve? Of conflict, co‐option, and cryptic choice
BioEssays·2015· 31 cited
Systematic imaging reveals features and changing localization of mRNAs in Drosophila development
eLife·2015· 153 citedOpen Access
Author response: Systematic imaging reveals features and changing localization of mRNAs in Drosophila development
2014Open Access
An Adaptive Threshold in Mammalian Neocortical Evolution
PLoS Biology·2014· 163 citedOpen Access
Introns and gene expression: Cellular constraints, transcriptional regulation, and evolutionary consequences
BioEssays·2014· 116 citedOpen Access
Towards an ecological understanding of morphological evolution
Journal of Experimental Zoology Part B Molecular and Developmental Evolution·2014· 3 cited
The Earliest Transcribed Zygotic Genes Are Short, Newly Evolved, and Different across Species
Cell Reports·2014· 244 citedOpen Access
An Adaptive Threshold in Mammalian Neocortical Evolution
2013· 10 citedOpen Access
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Frequent Co-authors

Pavel Tomančák(12), Iva Kelava(7), Éric Lewitus(5), Wieland Β. Huttner(4), David Walter(4), Barbara Horváth(3), Sebastian Łukasiak(3), Nikhil Gupta(3), Angelos Papadopoulos(3), Khalid Saeed(3), Ultan McDermott(3), Gregory J. Hannon(3), Douglas Ross‐Thriepland(3), Dave T. Gerrard(2), Patricia Heyn(2), Karla M. Neugebauer(2), Helena Jambor(2), Vineeth Surendranath(2), Pavel Mejstřík(2), Stephan Saalfeld(2)