Sebastian Łukasiak

AstraZeneca (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index670citations14works3.32yr avg
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Research Topics

RNA modifications and cancer(5), CRISPR and Genetic Engineering(4), Ubiquitin and proteasome pathways(4), Advanced biosensing and bioanalysis techniques(3), RNA and protein synthesis mechanisms(3)

Publications14 total

A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency
BMC Genomics·2025· 9 citedOpen Access
A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency
2024· 1 citedOpen Access
Abstract 2945: Using pooled minimal genome-wide sgRNA libraries to drive oncology drug discovery
Cancer Research·2024
Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell
Scientific Reports·2022· 24 citedOpen Access
Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell
Research Square (Research Square)·2022· 1 citedOpen Access
CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs
Nature Communications·2020· 75 citedOpen Access
Transcriptome Analysis of Infected and Bystander Type 2 Alveolar Epithelial Cells during Influenza A Virus Infection Reveals <i>In Vivo</i> Wnt Pathway Downregulation
Journal of Virology·2018· 57 citedOpen Access
The RNA transcriptome of <i>in vivo</i> influenza virus infection reveals unique gene expression profiles in type 2 alveolar epithelial cells.
The Journal of Immunology·2017
RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence
Science·2016· 181 citedOpen Access
USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis
Nature Communications·2010· 92 citedOpen Access
Elucidating the cause of FAT10 over-expression in liver and colon carcinomas
KOPS (University of Konstanz)·2009Open Access
Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon
Oncogene·2008· 151 cited
Quantitative Analysis of Gene Expression Relative to 18S rRNA in Carcinoma Samples Using the LightCycler® Instrument and a SYBR GreenI-based Assay: Determining FAT10 mRNA Levels in Hepatocellular Carcinoma
Methods in molecular biology·2008· 12 cited
The UBA Domains of NUB1L Are Required for Binding but Not for Accelerated Degradation of the Ubiquitin-like Modifier FAT10
Journal of Biological Chemistry·2006· 67 citedOpen Access

Frequent Co-authors

Martin Turner(4), Gunter Schmidtke(4), Marcus Groettrup(4), Elisa Monzón‐Casanova(3), Manuel D. Díaz‐Muñoz(3), Alex T. Kalinka(3), Nikhil Gupta(3), Angelos Papadopoulos(3), Khalid Saeed(3), Ultan McDermott(3), Gregory J. Hannon(3), Douglas Ross‐Thriepland(3), David Walter(3), C Schíller(2), Kai Breuhahn(2), Birte Kalveram(2), Aidan S. Hancock(2), Christopher J. Stairiker(2), Alina C. Boesteanu(2), Andrew Stubbs(2)