Antonio Llinàs

AstraZeneca (Australia) — Australia

Materials Science · Physical Sciences

23h-index2.5kcitations62works0.82yr avg
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Research Topics

Crystallization and Solubility Studies(26), X-ray Diffraction in Crystallography(14), Analytical Chemistry and Chromatography(13), Computational Drug Discovery Methods(11), Psoriasis: Treatment and Pathogenesis(4)

Publications62 total

Spirocyclopentane as a Novel Scaffold for Potent Ghrelin Receptor Full Agonists
Journal of Medicinal Chemistry·2025
RORγt inverse agonists demonstrating a margin between inhibition of IL-17A and thymocyte apoptosis
PLoS ONE·2025· 1 citedOpen Access
Impact of protein aggregation on the immunogenicity of a human monoclonal antibody following pulmonary administration in mice
International Journal of Pharmaceutics·2024· 1 citedOpen Access
Case study: cremophor EL-based liquid formulations as simple substitutes for amorphous solid dispersions in early preclinical <i>in vivo</i> studies
Journal of Pharmacy and Pharmacology·2024· 1 citedOpen Access
Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism
Journal of Medicinal Chemistry·2023· 24 citedOpen Access
Blinded Predictions and Post Hoc Analysis of the Second Solubility Challenge Data: Exploring Training Data and Feature Set Selection for Machine and Deep Learning Models
Journal of Chemical Information and Modeling·2023· 23 citedOpen Access
Blinded Predictions and Post-hoc Analysis of the Second Solubility Challenge Data: Exploring Training Data and Feature Set Selection for Machine and Deep Learning Models
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Blinded Predictions and Post-hoc Analysis of the Second Solubility Challenge Data: Exploring Training Data and Feature Set Selection for Machine and Deep Learning Models
2022Open Access
Influence of vertebral manipulations on the autonomic nervous system
Russian Osteopathic Journal·2021· 2 citedOpen Access
AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2
Journal of Medicinal Chemistry·2021· 24 citedOpen Access
The Solid State Landscape of the Sildenafil Drug
Journal of Pharmaceutical Sciences·2021· 9 citedOpen Access
Membrane Permeability in Cyclic Peptides is Modulated by Core Conformations
Journal of Chemical Information and Modeling·2020· 21 cited
Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds
ADMET & DMPK·2020Open Access
Findings of the Second Challenge to Predict Aqueous Solubility
Journal of Chemical Information and Modeling·2020· 67 cited
Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists
Journal of Medicinal Chemistry·2020· 23 citedOpen Access
Multisolvent Models for Solvation Free Energy Predictions Using 3D-RISM Hydration Thermodynamic Descriptors
Journal of Chemical Information and Modeling·2020· 16 cited
Multi-Solvent Models for Solvation Free Energy Predictions Using 3D-RISM Hydration Thermodynamic Descriptors
2020· 2 citedOpen Access
Multi-Solvent Models for Solvation Free Energy Predictions Using 3D-RISM Hydration Thermodynamic Descriptors
2020· 3 citedOpen Access
Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2
ACS Medicinal Chemistry Letters·2019· 18 cited
Solubility Challenge Revisited after Ten Years, with Multilab Shake-Flask Data, Using Tight (SD ∼ 0.17 log) and Loose (SD ∼ 0.62 log) Test Sets
Journal of Chemical Information and Modeling·2019· 60 cited
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Frequent Co-authors

Jonathan M. Goodman(9), Robert C. Glen(6), Ola Engkvist(6), David Scott Palmer(6), Michael I. Page(6), Ekaterina L. Ratkova(6), Rafael Barbas(6), Rafel Prohens(6), J. Burley(5), Yao Xiong(5), Nina Krutrök(5), Vigneshwari Subramanian(5), Frank Narjes(4), Stefan von Berg(4), Johan Jirholt(4), Jane McPheat(4), Eva Hansson(4), Rongfeng Chen(4), T. Hansson(4), Maxim V. Fedorov(4)