Thomas Hesson

Biogen (United States) — United States

Medicine · Health Sciences

14h-index875citations21works0.02yr avg
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Research Topics

Renin-Angiotensin System Studies(7), Receptor Mechanisms and Signaling(5), Protein Kinase Regulation and GTPase Signaling(4), Hepatitis C virus research(3), Mass Spectrometry Techniques and Applications(3)

Publications21 total

Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation <i>In Vivo</i>
Journal of Medicinal Chemistry·2021· 14 citedOpen Access
Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo
Journal of Medicinal Chemistry·2021· 32 citedOpen Access
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor
Acta Crystallographica Section F Structural Biology Communications·2020· 10 citedOpen Access
Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors
ACS Medicinal Chemistry Letters·2020· 22 citedOpen Access
Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors
Journal of Medicinal Chemistry·2019· 34 citedOpen Access
Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity
Bioorganic & Medicinal Chemistry Letters·2018· 5 citedOpen Access
Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension
Protein Science·2016· 22 citedOpen Access
Fully Activated MEK1 Exhibits Compromised Affinity for Binding of Allosteric Inhibitors U0126 and PD0325901
Biochemistry·2011· 16 cited
Design, high-level expression, purification and characterization of soluble fragments of the hepatitis C virus NS3 RNA helicase suitable for NMR-based drug discovery methods and mechanistic studies
Protein Engineering Design and Selection·2001· 8 citedOpen Access
Probing the Relationship between RNA-Stimulated ATPase and Helicase Activities of HCV NS3 Using 2‘-<i>O</i>-Methyl RNA Substrates
Biochemistry·2000· 18 cited
Structure of the hepatitis C virus RNA helicase domain
Nature Structural Biology·1997· 444 cited
Inactivation of the human cytomegalovirus protease by diisopropylfluorophosphate
Techniques in protein chemistry·1997
Isolation and purification of a biologically active human platelet-derived growth factor BB expressed in Escherichia coli
Protein Expression and Purification·1992· 16 cited
Immunological evidence that inactive renin is prorenin
Biochemical and Biophysical Research Communications·1985· 54 cited
Characterization of inactive renin ("prorenin") from renin-secreting tumors of nonrenal origin. Similarity to inactive renin from kidney and normal plasma.
Journal of Clinical Investigation·1984· 43 citedOpen Access
Reversible Acid-Activation of Inactive Renin: Evidence Favouring a Unimolecular Reaction
Clinical Science·1982· 9 cited
Biochemical similarity of partially purified inactive renins from human plasma and kidney.
Hypertension·1982· 25 citedOpen Access
Quantitation of Inactive Renin in Human and Dog Plasma: Techniques for Activation
Clinical and Experimental Hypertension Part A Theory and Practice·1982· 4 cited
Apparent Molecular Size Difference Between Plasma and Renal Inactive Renins
Clinical and Experimental Hypertension Part A Theory and Practice·1982· 1 cited
Detection and isolation of inactive, large molecular weight renin in human kidney and plasma.
Hypertension·1981· 58 citedOpen Access
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Frequent Co-authors

Steven A. Atlas(8), Jean E. Sealey(8), John H. Laragh(7), D.J. Marcotte(7), Zhili Xin(5), Paramasivam Murugan(5), Michael Cable(4), Martin Himmelbauer(4), J. Howard Jones(4), Istvan Enyedy(4), Kristopher King(4), Kerri Spilker(4), Rab Gilfillan(4), Felix González-López de Turiso(4), Hung V. Le(3), Patricia C Weber(3), Joseph C. Santoro(3), P. Rajesh Kumar(3), Thomas A. Patterson(3), B Dharmgrongartama(2)