Weisheng Xu

Biochemistry, Genetics and Molecular Biology · Life Sciences

6h-index2.4kcitations8works0.02yr avg
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Research Topics

Histone Deacetylase Inhibitors Research(8), Protein Degradation and Inhibitors(5), Ubiquitin and proteasome pathways(3), Peptidase Inhibition and Analysis(3), Redox biology and oxidative stress(2)

Publications8 total

Abstract LB-55: Histone deacetylase inhibitor causes DNA damage and apoptosis by downregulation of repair enzymes in cancer but not normal cells: Basis of resistance of normal cells to HDACi
Cancer Research·2010
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation
Proceedings of the National Academy of Sciences·2008· 15 citedOpen Access
Histone deacetylase inhibitors selectively suppress expression of HDAC7
Molecular Cancer Therapeutics·2007· 97 cited
Histone deacetylase inhibitors: molecular mechanisms of action
Oncogene·2007· 1.5k cited
Intrinsic apoptotic and thioredoxin pathways in human prostate cancer cell response to histone deacetylase inhibitor
Proceedings of the National Academy of Sciences·2006· 179 citedOpen Access
Role of pro- and anti-apoptotic proteins in prostate cancer cells sensitive and resistant to histone deacetylase inhibitor induced cell death
Cancer Research·2006
Induction of Polyploidy by Histone Deacetylase Inhibitor: A Pathway for Antitumor Effects
Cancer Research·2005· 120 citedOpen Access
The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin
Proceedings of the National Academy of Sciences·2002· 506 citedOpen Access

Frequent Co-authors

Paul A. Marks(7), Lang Ngo(5), Raphael B. Parmigiani(3), Gisela Perez(3), Milos Dokmanovic(3), P A Marks(1), Lisa M. Butler(1), Xianbo Zhou(1), Howard I. Scher(1), Richard A. Rifkind(1), Victoria M. Richon(1), Chang-Yun Gui(1), Cathy Clarke(1), Gisela Venta-Perez(1), Hediye Erdjument‐Bromage(1), Mariana Yaneva(1), Paul Tempst(1), Perez Gisela(1), Ju‐Hee Lee(1), Megan L. Choy(1)