Jacqueline F. Spencer

Saint Louis University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index1.4kcitations44works5.02yr avg
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Research Topics

Virus-based gene therapy research(39), Viral Infectious Diseases and Gene Expression in Insects(16), Viral gastroenteritis research and epidemiology(15), CAR-T cell therapy research(14), Cytomegalovirus and herpesvirus research(11)

Publications44 total

Longitudinal Monitoring of the Effects of Anti-Adenoviral Treatment Regimens in a Permissive In Vivo Model
Viruses·2024Open Access
NPP-669, a prodrug of cidofovir, is highly efficacious against human adenovirus infection in the permissive Syrian hamster model
Antimicrobial Agents and Chemotherapy·2024· 5 citedOpen Access
Oral USC-093, a novel homoserinamide analogue of the tyrosinamide (S)-HPMPA prodrug USC-087 has decreased nephrotoxicity while maintaining antiviral efficacy against human adenovirus infection of Syrian hamsters
Antiviral Research·2024· 10 citedOpen Access
Oral Usc-093, a Novel Homoserinamide Analogue of the Tyrosinamide (S)-Hpmpa Prodrug Usc-087 Has Decreased Nephrotoxicity While Maintaining Antiviral Efficacy Against Human Adenovirus Infection of Syrian Hamsters
SSRN Electronic Journal·2023Open Access
NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin
Molecular Pharmaceutics·2022· 16 citedOpen Access
Characterization of cells susceptible to SARS-COV-2 and methods for detection of neutralizing antibody by focus forming assay
2020· 5 cited
Filociclovir Is a Potent<i>In Vitro</i>and<i>In Vivo</i>Inhibitor of Human Adenoviruses
Antimicrobial Agents and Chemotherapy·2020· 18 citedOpen Access
Generation and characterization of an <i>IL2RG</i> knockout Syrian hamster model for XSCID and HAdV-C6 infection in immunocompromised patients
Disease Models & Mechanisms·2020· 17 citedOpen Access
Drug development against human adenoviruses and its advancement by Syrian hamster models
FEMS Microbiology Reviews·2019· 35 cited
Characterization of an N-Terminal Non-Core Domain of RAG1 Gene Disrupted Syrian Hamster Model Generated by CRISPR Cas9
Viruses·2018· 29 citedOpen Access
USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses
Antiviral Research·2018· 28 cited
Male Syrian hamsters are more susceptible to intravenous infection with species C human adenoviruses than are females
Virology·2017· 15 cited
Combination therapy with brincidofovir and valganciclovir against species C adenovirus infection in the immunosuppressed Syrian hamster model allows for substantial reduction of dose for both compounds
Antiviral Research·2017· 11 cited
Anti-adenoviral Artificial MicroRNAs Expressed from AAV9 Vectors Inhibit Human Adenovirus Infection in Immunosuppressed Syrian Hamsters
Molecular Therapy — Nucleic Acids·2017· 24 citedOpen Access
HAdV-C6 Is a More Relevant Challenge Virus than HAdV-C5 for Testing Antiviral Drugs with the Immunosuppressed Syrian Hamster Model
Viruses·2017· 14 citedOpen Access
Pathology in Permissive Syrian Hamsters after Infection with Species C Human Adenovirus (HAdV-C) Is the Result of Virus Replication: HAdV-C6 Replicates More and Causes More Pathology than HAdV-C5
Journal of Virology·2017· 37 citedOpen Access
16. STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus Type 5, Revealing an Important Role of Type I Interferon Response in Viral Control
Molecular Therapy·2016Open Access
Correction: STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control
PLoS Pathogens·2016· 1 citedOpen Access
Transcriptome sequencing and development of an expression microarray platform for liver infection in adenovirus type 5-infected Syrian golden hamsters
Virology·2015· 20 citedOpen Access
STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control
PLoS Pathogens·2015· 55 citedOpen Access
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Frequent Co-authors

Károly Tóth(40), William S.M. Wold(40), Ann E. Tollefson(30), Baoling Ying(24), John E. Sagartz(9), Konstantin Doronin(8), Debanjan Dhar(7), Maria Thomas(6), Elena V. Shashkova(6), R. Mark L. Buller(5), Drew L. Lichtenstein(5), Zhongde Wang(5), M Kuppuswamy(4), Il‐Keun Kong(4), Dawn Reyna(4), Elke Lipka(4), Marie C. La Regina(3), Mohan Kuppuswamy(3), Debabrata Patra(3), Louis A. Zumstein(3)