Ellen M. Dobrusin

Medicine · Health Sciences

18h-index1.9kcitations28works0.02yr avg

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Research Topics

Publications28 total

Inhibition of binding of phospholipase Cγ1 SH2 domains to phosphorylated epidermal growth factor receptor by phosphorylated peptides

28 cited

International journal of peptide & protein research·2009· 28 citedOpen Access

Synthesis and structure–activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases

31 cited

European Journal of Medicinal Chemistry·2007· 31 citedOpen Access

4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Inhibitors of the Checkpoint Kinase Wee1. Structure−Activity Relationships for Chromophore Modification and Phenyl Ring Substitution

107 cited

Journal of Medicinal Chemistry·2006· 107 citedOpen Access

2‐Aminoquinazoline Inhibitors of Cyclin‐Dependent Kinases.

ChemInform·2005

Structure—Activity Relationships for 2‐Anilino‐6‐phenylpyrido[2,3‐d]pyrimidin‐7(8H)‐ones as Inhibitors of the Cellular Checkpoint Kinase Wee1.

2 cited

ChemInform·2005· 2 cited

2-Aminoquinazoline inhibitors of cyclin-dependent kinases

24 cited

Bioorganic & Medicinal Chemistry Letters·2005· 24 citedOpen Access

Pyrido[2,3-d]pyrimidin-7-ones as Specific Inhibitors of Cyclin-Dependent Kinase 4

148 cited

Journal of Medicinal Chemistry·2005· 148 citedOpen Access

Structure–activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1

60 cited

Bioorganic & Medicinal Chemistry Letters·2005· 60 citedOpen Access

Synthesis and SAR development of PD 0325901, a potent and highly bioavailable MEK inhibitor.

2 cited

Cancer Research·2004· 2 cited

Unequivocal Synthesis of 6- and 7-Substituted Thiazolo[3,2-a]benzimidazoles

Elsevier eBooks·2003

Cell Cycle and Biochemical Effects of PD 0183812

107 cited

Journal of Biological Chemistry·2001· 107 citedOpen Access

Pyrido[2,3-d]pyrimidin-7-one Inhi-bitors of Cyclin-Dependent Kinases.

2 cited

Journal of Medicinal Chemistry·2001· 2 cited

Pyrido[2,3-d]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases

152 cited

Journal of Medicinal Chemistry·2000· 152 citedOpen Access

Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor

178 cited

Journal of Medicinal Chemistry·1999· 178 citedOpen Access

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

417 cited

Proceedings of the National Academy of Sciences·1998· 417 citedOpen Access

C-Terminal Modifications of Histidyl-N-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice

27 cited

Journal of Medicinal Chemistry·1997· 27 citedOpen Access

Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases

107 cited

Journal of Medicinal Chemistry·1997· 107 citedOpen Access

Determinants of Substrate Recognition in the Protein-tyrosine Phosphatase, PTP1

28 cited

Journal of Biological Chemistry·1996· 28 citedOpen Access

Differentiation of peptide molecular recognition by phospholipase Cγ‐1 Src homology‐2 domain and a mutant Tyr phosphatase PTP1bC215S

2 cited

Protein Science·1995· 2 citedOpen Access

ChemInform Abstract: Tyrosine Kinase Inhibitors. Part 3. Structure‐Activity Relationships for Inhibition of Protein Tyrosine Kinases by Nuclear‐Substituted Derivatives of 2,2′‐Dithiobis(1‐methyl‐N‐phenyl‐1H‐indole‐3‐ carboxamide).

3 cited

ChemInform·1994· 3 cited

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Frequent Co-authors

David W. Fry(15), Dennis J. McNamara(15), William A. Denny(9), Paul R. Keller(7), Wilbur R. Leopold(7), Brian D. Palmer(7), Gordon W. Rewcastle(7), Jeff B. Smaill(6), Patricia J. Harvey(5), Peter L. Toogood(5), Alan J. Kraker(5), Alexander J. Bridges(4), Derek Maclean(4), Tomi K. Sawyer(4), Stuart J. Decker(4), Alan R. Saltiel(4), Susanne Trumpp-Kallmeyer(3), Ali Fattaey(3), Michelle D. Garrett(3), John Quin(3)