Bernard Refouvelet

Inserm — France

Chemistry · Physical Sciences

20h-index1.4kcitations75works1.82yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Synthesis and biological activity(26), Cholinesterase and Neurodegenerative Diseases(20), Synthesis of Organic Compounds(12), Synthesis and Characterization of Heterocyclic Compounds(12), Computational Drug Discovery Methods(11)

Publications74 total

Multicomponent Synthesis of Multi-Target Quinazolines Modulating Cholinesterase, Oxidative Stress, and Amyloid Aggregation Activities for the Therapy of Alzheimer’s Disease
Molecules·2025· 1 citedOpen Access
Synthesis and Anti‐Inflammatory Activity of Spiropyrimido[4,5‐ <i>d</i> ]pyrimidine Derivatives
ChemistrySelect·2025
Synthesis and evaluation of lipoic acid – donepezil hybrids for Alzheimer’s disease using a straightforward strategy
Bioorganic & Medicinal Chemistry Letters·2024· 3 citedOpen Access
Discovery of New Highly Potent Histamine H<sub>3</sub> Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors
ACS Chemical Neuroscience·2024· 3 citedOpen Access
Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment
International Journal of Molecular Sciences·2023· 9 citedOpen Access
Multicomponent Reactions As a Privileged Tool for Multitarget-Directed Ligand Strategies in Alzheimer’s Disease Therapy
Future Medicinal Chemistry·2022· 7 cited
Latest Progress in the Development of Multitarget Ligands for Alzheimer's Disease Based on the Hantzsch Reaction
Future Medicinal Chemistry·2022· 5 cited
(±)-<b>BIGI-3h</b>: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer’s Disease
ACS Chemical Neuroscience·2021· 33 citedOpen Access
Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives
International Journal of Molecular Sciences·2020· 14 citedOpen Access
Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy
International Journal of Molecular Sciences·2020· 11 citedOpen Access
Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels
Molecules·2020· 19 citedOpen Access
Synthesis of New Ferulic/Lipoic/Comenic Acid-Melatonin Hybrids as Antioxidants and Nrf2 Activators via Ugi Reaction
Future Medicinal Chemistry·2019· 18 cited
Synthesis and Biological Evaluation of Novel Chromone+Donepezil Hybrids for Alzheimer’s Disease Therapy
Current Alzheimer Research·2019· 9 cited
Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy
Journal of Enzyme Inhibition and Medicinal Chemistry·2019· 56 citedOpen Access
Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy
Journal of Enzyme Inhibition and Medicinal Chemistry·2018· 21 citedOpen Access
The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
Journal of Medicinal Chemistry·2016· 101 citedOpen Access
Synthesis, regioselectivity, and DFT analysis of new antioxidant pyrazolo[4,3-c]quinoline-3,4-diones
Monatshefte für Chemie - Chemical Monthly·2016· 16 cited
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
Progress in Neurobiology·2016· 177 citedOpen Access
Electrochemical Analysis of Thiourea on Platinum in Non-Aqueous Electrolyte
2015
Donepezil–Ferulic Acid Hybrids as Anti-Alzheimer Drugs
Future Medicinal Chemistry·2015· 67 cited
page 1 of 4Next →

Frequent Co-authors

Lhassane Ismaïli(30), José Marco‐Contelles(15), Alain Xicluna(14), Hélène Martin(8), Yves Jacquot(8), Jean-François Robert(7), Isabel Iriepa(7), Mohamed Benchekroun(6), Marc Pudlo(6), Vincent Luzet(6), J. F. Robert(6), Laurent Nicod(5), Irène Pachón-Angona(5), Laurent Bermont(5), Yves Claude Guillaume(5), Isabelle Tomassoli(4), Rudolf Andrýs(4), Ignacio Moraleda(4), Kamil Musílek(4), Guy Leclercq(4)