Irène Pachón-Angona

ETH Zurich — Switzerland

Medicine · Health Sciences

8h-index330citations14works3.72yr avg
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Research Topics

Cholinesterase and Neurodegenerative Diseases(10), Computational Drug Discovery Methods(8), Synthesis and biological activity(6), Multicomponent Synthesis of Heterocycles(2), Biochemical Acid Research Studies(2)

Publications14 total

Selective inhibition of <i>Mycobacterium tuberculosis</i> GpsI unveils a novel strategy to target the RNA metabolism
Nucleic Acids Research·2025Open Access
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties
Pharmaceutics·2024· 6 citedOpen Access
Combining <i>de novo</i> molecular design with semiempirical protein–ligand binding free energy calculation
RSC Advances·2024· 5 citedOpen Access
Leveraging molecular structure and bioactivity with chemical language models for de novo drug design
Nature Communications·2023· 146 citedOpen Access
Ferulic acid derivatives block coronaviruses HCoV-229E and SARS-CoV-2 replication in vitro
Scientific Reports·2022· 16 citedOpen Access
Multicomponent Reactions As a Privileged Tool for Multitarget-Directed Ligand Strategies in Alzheimer’s Disease Therapy
Future Medicinal Chemistry·2022· 7 cited
Synthesis of New Hantzsch Adducts Showing Ca <sup>2+</sup> Channel Blockade capacity, Cholinesterase Inhibition and Antioxidant Power
Future Medicinal Chemistry·2021· 5 cited
Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives
International Journal of Molecular Sciences·2020· 14 citedOpen Access
Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy
Molecules·2020· 15 citedOpen Access
Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels
Molecules·2020· 19 citedOpen Access
Synthesis of New Ferulic/Lipoic/Comenic Acid-Melatonin Hybrids as Antioxidants and Nrf2 Activators via Ugi Reaction
Future Medicinal Chemistry·2019· 18 cited
Synthèse multicomposants et évaluation pharmacologique de molécules multicibles par des réactions d’Ugi et de Hantzsch comme solution pour la maladie d’Alzheimer
2019
Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy
Journal of Enzyme Inhibition and Medicinal Chemistry·2019· 56 citedOpen Access
Synthesis, antioxidant and Aβ anti-aggregation properties of new ferulic, caffeic and lipoic acid derivatives obtained by the Ugi four-component reaction
Bioorganic Chemistry·2018· 23 cited

Frequent Co-authors

Lhassane Ismaïli(10), Hélène Martin(7), José Marco‐Contelles(6), Bernard Refouvelet(5), María Jesús Oset‐Gasque(4), Maciej Maj(4), Krzysztof Jóźwiak(4), Gisbert Schneider(3), Isabel Iriepa(3), Artur Wnorowski(3), Leandro Cotos(2), Kenneth Atz(2), Vincent Luzet(2), Ignacio Moraleda(2), Daniel Diez‐Iriepa(2), Solene Daniel(2), Alexandre Bonet(2), Michaël Moret(1), Shen Yan(1), Cyrill Brunner(1)