Mohamad‐Gabriel Alameh

Children's Hospital of Philadelphia — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

47h-index8.5kcitations167works17.22yr avg
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Research Topics

RNA Interference and Gene Delivery(72), SARS-CoV-2 and COVID-19 Research(35), Immunotherapy and Immune Responses(24), Animal Virus Infections Studies(24), Advanced biosensing and bioanalysis techniques(19)

Publications167 total

Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B-specific CD4 <sup>+</sup> T cell responses
2026Open Access
Automated and Parallelized Microfluidic Generation of Large and Precisely Defined Lipid Nanoparticle Libraries
ACS Nano·2025· 1 cited
An influenza HA mRNA-LNP vaccine induces potent responses in newborn nonhuman primates that enhance protection from challenge
npj Vaccines·2025· 1 citedOpen Access
mRNA vaccines targeting Leptospira immunoglobulin-like proteins confer partial protection in a hamster model of leptospirosis
Vaccine·2025Open Access
Distinct innate immune activation profiles of an mRNA-lipid nanoparticle vaccine compared to the empty lipid nanoparticle
Vaccine·2025Open Access
Liver-directed base editing of ABCC6 prevents ectopic calcification in a variant-humanized mouse model of pseudoxanthoma elasticum
Molecular Therapy — Nucleic Acids·2025Open Access
Toward ‘n of one’ gene therapies: Scalable ex vivo adenine base editing via lipid nanoparticles in a sickle cell disease model
Blood·2025Open Access
Expansion of human hematopoietic stem cells by inhibiting translation
Blood·2025Open Access
The effect of Natural Killer cell depletion and inhibition on mRNA vaccine immunogenicity and reactogenicity 3829
The Journal of Immunology·2025Open Access
TLR4 recognizes ionizable lipid nanoparticles to induce NF-kB and IRF responses 2951
The Journal of Immunology·2025Open Access
Clostridioides difficile toxin B inhibits antigen-specific adaptive immune responses through glucosyltransferase-dependent activity 3906
The Journal of Immunology·2025Open Access
Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs
Nature Biomedical Engineering·2025· 5 citedOpen Access
Lipid nanoparticle co-delivery of mRNA and a small molecule drug for oral cancer chemoimmunotherapy
2025Open Access
Systemic mRNA-LNP administration in fetuses improves survival in a mouse model of spinal muscular atrophy
Molecular Therapy — Methods & Clinical Development·2025· 3 citedOpen Access
Allergen-specific mRNA–lipid nanoparticle therapy for prevention and treatment of experimental allergy in mice
Journal of Clinical Investigation·2025· 3 citedOpen Access
Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity
Mucosal Immunology·2025· 1 citedOpen Access
Immunogenicity and safety of ‘Comvigen’, a bivalent SARS-CoV-2 vaccine, in comparison to Comirnaty bivalent vaccine in Thailand: a phase 2, non-inferiority randomised trial
The Lancet Regional Health - Southeast Asia·2025Open Access
Comparative Analysis of Chitosan, Lipid Nanoparticles, and Alum Adjuvants in Recombinant SARS-CoV-2 Vaccine: An Evaluation of Their Immunogenicity and Serological Efficacy
UNC Libraries·2025Open Access
<i>Clostridioides difficile</i> toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity
2025Open Access
Author Correction: Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity
Nature Biomedical Engineering·2025· 1 citedOpen Access
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Frequent Co-authors

Drew Weissman(42), Michael J. Mitchell(22), Xuexiang Han(15), Ningqiang Gong(13), Ying K. Tam(12), Lulu Xue(11), Rakan El‐Mayta(10), Norbert Pardi(9), Kelsey L. Swingle(9), Margaret M. Billingsley(9), Alex G. Hamilton(8), Paulo J.C. Lin(7), Sarah J. Shepherd(7), Marc Lavertu(7), Junchao Xu(6), Gan Zhao(6), Marshall S. Padilla(6), James J. Knox(5), Hiromi Muramatsu(5), Garima Dwivedi(5)