Charles J. Kotzer

GlaxoSmithKline (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index737citations16works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(6), Asthma and respiratory diseases(4), Neuropeptides and Animal Physiology(4), Chronic Obstructive Pulmonary Disease (COPD) Research(3), Atomic and Subatomic Physics Research(2)

Publications16 total

Protective Effect of a Human Pregnancy-Associated Plasma Protein A IgG Monoclonal Antibody in an Orthologous ADPKD Mouse Model
Journal of the American Society of Nephrology·2025
Novel Neutralizing Monoclonal Antibody (mAb) Against Pregnancy-Associated Plasma Protein A (PAPPA) for the Treatment of ADPKD
Journal of the American Society of Nephrology·2025
Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs
Mutagenesis·2016· 12 citedOpen Access
Pharmacological Characterization of GSK573719 (Umeclidinium): A Novel, Long-Acting, Inhaled Antagonist of the Muscarinic Cholinergic Receptors for Treatment of Pulmonary Diseases
Journal of Pharmacology and Experimental Therapeutics·2013· 76 cited
Regional function-structure relationships in lungs of an elastase murine model of emphysema
Journal of Applied Physiology·2011· 14 citedOpen Access
The pre-clinical pharmacology of the inhaled muscarinic antagonist GSK573719 predicts once-daily clinical dosing
2011· 15 cited
Serial MRI characterization of the functional and morphological changes in mouse lung in response to cardiac remodeling following myocardial infarction
Magnetic Resonance in Medicine·2011· 10 citedOpen Access
Manual Vs. Automated Assessment Of Mean Linear Intercept Using Systematic Uniform Random Sampling Combined With Statistical Parameter Optimization
2011
A Noninvasive [99mTc]DTPA SPECT/CT Imaging Methodology as a Measure of Lung Permeability in a Guinea Pig Model of COPD
Molecular Imaging and Biology·2010· 14 cited
Are Preclinical Cigarette Smoke- Induced COPD Models Sensitive To Steroids?
2010
Nonpeptide Tachykinin Receptor Antagonists. III. SB 235375, a Low Central Nervous System-Penetrant, Potent and Selective Neurokinin-3 Receptor Antagonist, Inhibits Citric Acid-Induced Cough and Airways Hyper-reactivity in Guinea Pigs
Journal of Pharmacology and Experimental Therapeutics·2002· 90 citedOpen Access
SB 239063, a Potent p38 MAP Kinase Inhibitor, Reduces Inflammatory Cytokine Production, Airways Eosinophil Infiltration, and Persistence
Journal of Pharmacology and Experimental Therapeutics·2000· 244 cited
The Antitussive Activity of δ-Opioid Receptor Stimulation in Guinea Pigs
Journal of Pharmacology and Experimental Therapeutics·2000· 31 cited
The antitussive activity of delta-opioid receptor stimulation in guinea pigs.
PubMed·2000· 67 cited
Antiasthmatic Activity of the Second-Generation Phosphodiesterase 4 (PDE4) Inhibitor SB 207499 (Ariflo) in the Guinea Pig
Journal of Pharmacology and Experimental Therapeutics·1998· 70 cited
Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.
Journal of Pharmacology and Experimental Therapeutics·1994· 94 cited

Frequent Co-authors

Douglas W.P. Hay(7), David C. Underwood(6), Mark A. Luttmann(5), Ruth R. Osborn(4), Gregory A. Logan(4), Steven Bochnowicz(3), Giuseppe Giardina(3), James J. Foley(3), William L. Rumsey(3), Patricia L. Podolin(3), Brian Bolognese(3), Edward F. Webb(2), Don E. Griswold(2), Theodore J. Torphy(2), Dulcie B. Schmidt(2), Henry M. Sarau(2), M Salmon(2), Dramane I. Lainé(2), Giulio Dondio(2), Paola Petrillo(2)