Behnoush Hajian

Broad Institute — United States

Medicine · Health Sciences

8h-index695citations21works8.52yr avg
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Research Topics

Tuberculosis Research and Epidemiology(9), Mycobacterium research and diagnosis(5), Antibiotic Resistance in Bacteria(3), Antimicrobial Resistance in Staphylococcus(3), Synthesis and biological activity(2)

Publications21 total

Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype
2025Open Access
Synthetic genomes unveil the effects of synonymous recoding
2024· 17 citedOpen Access
Discovery of a structural class of antibiotics with explainable deep learning
Nature·2023· 357 citedOpen Access
Correction to “An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with <i>In Vivo</i> Efficacy against Drug-Resistant Gram-Negative Infections”
ACS Central Science·2022· 2 citedOpen Access
An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with <i>In Vivo</i> Efficacy against Drug-Resistant Gram-Negative Infections
ACS Central Science·2022· 71 citedOpen Access
Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex
Nature·2022· 82 citedOpen Access
Abstract LB029: Comprehensive structure-function evaluation of the SHOC2 holophosphatase reveals disease mechanisms and therapeutic opportunities
Cancer Research·2022
Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents
Cell chemical biology·2019· 66 citedOpen Access
Structural and Biochemical Studies of Dihydrofolate Reductase from <i>Streptococcus pyogenes</i> as a Target for Antifolate Antibiotics
2018Open Access
Mycobacterium tuberculosis Rv2671 complexed with beta-NADPH and 6-ethyl-5-{(3S)-3-[2-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine
2018
Homo sapiens dihydrofolate reductase complexed with beta-NADPH and 3'-[(2R)-4-(2,4-diamino-6-ethylphenyl)but-3-yn-2-yl]-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid
2018
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid
2018
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-2-hydroxybenzene-1-carbonyl)-L-glutamic acid
2018
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid
2018
Propargyl-Linked Antifolates as Inhibitors of the Folate Biosynthetic Pathway in Mycobacterium tuberculosis and M. avium
OpenCommons - UConn (University of Connecticut)·2018· 1 citedOpen Access
Drugging the Folate Pathway in Mycobacterium Tuberculosis: The Role of Multi-Targeting Agents
SSRN Electronic Journal·2018· 1 citedOpen Access
MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates
Cell chemical biology·2016· 31 citedOpen Access
Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis
PLoS ONE·2016· 28 citedOpen Access
Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens
ACS Medicinal Chemistry Letters·2016· 36 citedOpen Access
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta- NADPH and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (UCP1106)
2016
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Frequent Co-authors

Dennis L. Wright(11), Eric W. Scocchera(7), J. Krucinska(5), Carolyn Shoen(3), Kishore Viswanathan(3), Narendran G-Dayanandan(3), Michael H. Cynamon(3), Stephanie M. Reeve(3), Santosh Keshipeddy(3), Amy C. Anderson(3), Jason J. Kwon(2), Yuemin Bian(2), Alvaro J. Amor(2), James R. Fuller(2), Cara V. Fraley(2), Abbey M. Sykes(2), Jonathan So(2), Laura Baker(2), David L. Mayhew(2), Nicole S. Persky(2)