Stephanie M. Reeve

St. Jude Children's Research Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index449citations31works6.02yr avg
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Research Topics

Antibiotic Resistance in Bacteria(10), Antimicrobial Resistance in Staphylococcus(8), Click Chemistry and Applications(6), Tuberculosis Research and Epidemiology(4), Antibiotics Pharmacokinetics and Efficacy(4)

Publications31 total

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria
ACS Infectious Diseases·2025Open Access
Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in<i>Mycobacterium</i>abscessus
Proceedings of the National Academy of Sciences·2024· 12 citedOpen Access
A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance
Nature Communications·2022· 39 citedOpen Access
Synthesis and Structure–Activity Relationship of Thioacetamide-Triazoles against Escherichia coli
Molecules·2022· 8 citedOpen Access
Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus
PLoS Computational Biology·2022· 14 citedOpen Access
A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance
2022· 2 citedOpen Access
Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria
ACS Infectious Diseases·2021· 16 cited
Combating Multidrug‐Resistant Bacteria by Integrating a Novel Target Site Penetration and Receptor Binding Assay Platform Into Translational Modeling
Clinical Pharmacology & Therapeutics·2021· 12 citedOpen Access
Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins
The Journal of Antibiotics·2021· 13 citedOpen Access
1233. Identification of Novel Inhibitors of <i>Clostridioides difficile</i> Enoyl-Reductase II (FabK) by High-Throughput Virtual and Experimental Screening
Open Forum Infectious Diseases·2020Open Access
Chiral evasion and stereospecific antifolate resistance in <i>Staphylococcus aureus</i>
2020Open Access
A Rare Bacteria: Lactobacillus Rhamnosus in Pediatric Lung Abscess
2020· 2 citedOpen Access
Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant<i>Klebsiella pneumoniae</i>and<i>Enterobacter cloacae</i>
mBio·2020· 20 citedOpen Access
Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria
ACS Infectious Diseases·2019· 24 citedOpen Access
Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant <i>Staphylococcus aureus</i>
ACS Infectious Diseases·2019· 29 cited
Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates
Drug Metabolism and Disposition·2019· 8 citedOpen Access
Staphylococcus aureus Dihydrofolate reductase in complex with NADPH and Methotrexate
2019
Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant <i>Staphylococcus aureus</i>
2019Open Access
Understanding and Overcoming Antifolate Resistance in Methicillin-resistant Staphylococcus aureus
OpenCommons - UConn (University of Connecticut)·2017
OSPREY Predicts Resistance Mutations Using Positive and Negative Computational Protein Design
Methods in molecular biology·2016· 18 citedOpen Access
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Frequent Co-authors

Richard Lee(11), Dennis L. Wright(11), Amy C. Anderson(10), Santosh Keshipeddy(8), Bruce R. Donald(6), Suresh Dharuman(6), Adegoke A. Ojewole(5), Pablo Gaínza(4), Eric W. Scocchera(4), Jeremy B. Alverson(4), J. Krucinska(4), Graham T. Holt(4), Marcel S. Frenkel(4), Miranda J. Wallace(4), Robin B. Lee(4), Jürgen B. Bulitta(4), Michael N. Lombardo(3), Behnoush Hajian(3), Nigel D. Priestley(3), Narendran G-Dayanandan(3)