Michael A. Jacobetz

Medicine · Health Sciences

12h-index9.2kcitations15works0.02yr avg
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Research Topics

Pancreatic and Hepatic Oncology Research(10), Epigenetics and DNA Methylation(3), Cancer Cells and Metastasis(3), Cancer, Hypoxia, and Metabolism(2), Proteoglycans and glycosaminoglycans research(2)

Publications15 total

Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment
BioMed Research International·2014· 115 citedOpen Access
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
Gut·2012· 1.1k citedOpen Access
Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma
The Journal of Experimental Medicine·2012· 94 citedOpen Access
Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer
Oncogene·2011· 99 cited
A novel method for quantification of gemcitabine and its metabolites 2′,2′-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC–MS/MS: comparison with 19F NMR spectroscopy
Cancer Chemotherapy and Pharmacology·2011· 54 citedOpen Access
Stromal biology and therapy in pancreatic cancer
Gut·2010· 740 cited
Abstract PR2: Therapeutic intervention targeting a Hedgehog-dependent barrier to drug delivery in pancreatic cancer
Clinical Cancer Research·2010
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Science·2009· 3.1k citedOpen Access
A Phase I Trial of the Oral, Multikinase Inhibitor Sorafenib in Combination with Carboplatin and Paclitaxel
Clinical Cancer Research·2008· 146 citedOpen Access
Genetically Engineered Mice Harboring RAS Mutations as Models of Human Cancer: in Medias RAS
2006
Abstracts
Cancer Biomarkers·2005Open Access
Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects
Cancer Cell·2004· 810 citedOpen Access
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Cancer Cell·2004· 81 citedOpen Access
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Cancer Cell·2003· 2.5k citedOpen Access
Suppression of BRAF(V599E) in human melanoma abrogates transformation.
PubMed·2003· 416 cited

Frequent Co-authors

David A. Tuveson(15), Sunil R. Hingorani(7), Ralph H. Hruban(5), Kenneth P. Olive(4), Catrina E. King(4), Tyler Jacks(4), Natalie Cook(4), Aarthi Gopinathan(3), Mae A. Goldgraben(3), Meredith E. Caldwell(3), Christine Feig(3), William Howat(3), Emanuel F. Petricoin(3), Anirban Maitra(3), Sally Ross(3), Thomas P. Conrads(3), Timothy D. Veenstra(3), Ben A. Hitt(3), Yoshiya Kawaguchi(3), Lance A. Liotta(3)