Jeffrey L. Americo

National Institutes of Health — United States

Immunology and Microbiology · Life Sciences

26h-index2.6kcitations44works26.82yr avg
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Research Topics

Poxvirus research and outbreaks(35), Herpesvirus Infections and Treatments(22), Immunotherapy and Immune Responses(13), Bacillus and Francisella bacterial research(13), Virus-based gene therapy research(12)

Publications44 total

A functional approach to analyze the genetic basis for differences in virulence of monkeypox virus clades
Emerging Microbes & Infections·2025· 6 citedOpen Access
Mpox mRNA-1769 vaccine inhibits orthopoxvirus replication at intranasal, intrarectal, and cutaneous sites of inoculation
npj Vaccines·2024· 9 citedOpen Access
Mpox mRNA-1769 Vaccine Inhibits Orthopoxvirus Replication at Intranasal, Intrarectal, and Cutaneous Sites of Inoculation
2024· 1 citedOpen Access
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates
Cell·2024· 91 citedOpen Access
An mpox virus mRNA-lipid nanoparticle vaccine confers protection against lethal orthopoxviral challenge
Science Translational Medicine·2023· 94 cited
Protection from SARS-CoV-2 Variants by MVAs expressing matched or mismatched S administered intranasally to mice
npj Vaccines·2023· 4 citedOpen Access
Virulence differences of mpox (monkeypox) virus clades I, IIa, and IIb.1 in a small animal model
Proceedings of the National Academy of Sciences·2023· 199 citedOpen Access
A monkeypox mRNA-lipid nanoparticle vaccine targeting virus binding, entry, and transmission drives protection against lethal orthopoxviral challenge
2022· 14 citedOpen Access
Enhanced Protection from SARS-CoV-2 Variants by MVA-Based Vaccines Expressing Matched or Mismatched S Proteins Administered Intranasally to hACE2 Mice
2022Open Access
Virulence Differences of Monkeypox Virus Clades 1, 2a and 2b.1 in a Small Animal Model
2022· 4 cited
Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infection
Proceedings of the National Academy of Sciences·2022· 61 citedOpen Access
Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects
mBio·2022· 3 citedOpen Access
Spontaneous and Targeted Mutations in the Decapping Enzyme Enhance Replication of Modified Vaccinia Virus Ankara (MVA) in Monkey Cells
Journal of Virology·2021· 5 citedOpen Access
One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection
Proceedings of the National Academy of Sciences·2021· 71 citedOpen Access
Loss of the Vaccinia Virus 35-Amino-Acid Hydrophobic O3 Protein Is Partially Compensated by Mutations in the Transmembrane Domains of Other Entry Proteins
Journal of Virology·2021· 4 citedOpen Access
MVA Vector Vaccines Inhibit SARS CoV-2 Replication in Upper and Lower Respiratory Tracts of Transgenic Mice and Prevent Lethal Disease
2021· 10 citedOpen Access
Natural killer cells expanded in vivo or ex vivo with IL-15 overcomes the inherent susceptibility of CAST mice to lethal infection with orthopoxviruses
PLoS Pathogens·2020· 57 citedOpen Access
Lymph node conduits transport virions for rapid T cell activation
The Journal of Immunology·2019· 2 cited
Lymph node conduits transport virions for rapid T cell activation
Nature Immunology·2019· 104 citedOpen Access
Growth and Purification of Vaccinia Virus Stocks for MPM Imaging
Methods in molecular biology·2019· 3 citedOpen Access
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Frequent Co-authors

Bernard Moss(39), Patricia L. Earl(35), Catherine A. Cotter(13), Linda S. Wyatt(7), Alec W. Freyn(5), Tiffany R. Frey(5), Jay W. Hooper(5), Andrea Carfı́(5), Gary H. Cohen(4), Roselyn J. Eisenberg(4), Eric M. Mucker(4), Andrea S. Weisberg(4), Wei Xiao(4), Ruikang Liu(4), John W. Huggins(3), Inger K. Damon(3), Scott K. Smith(3), Glennys V. Reynoso(3), John P. Shannon(3), Heather D. Hickman(3)