Gregory P. Roth

Sanford Burnham Prebys Medical Discovery Institute — United States

Chemistry · Physical Sciences

31h-index2.7kcitations164works0.02yr avg
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Research Topics

Catalytic Cross-Coupling Reactions(18), Chemical Synthesis and Analysis(17), Asymmetric Synthesis and Catalysis(16), Analytical Chemistry and Chromatography(15), Catalytic C–H Functionalization Methods(12)

Publications164 total

Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors
ACS Medicinal Chemistry Letters·2017· 37 citedOpen Access
Design and structural characterization of a bivalent MAP kinase inhibitor
Acta Crystallographica Section A Foundations and Advances·2017Open Access
MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling
Journal of Clinical Investigation·2016· 69 citedOpen Access
Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules Is Regulated by Electrochemical Oxidation Potential
ASN NEURO·2015· 21 citedOpen Access
Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins
SLAS DISCOVERY·2014· 28 citedOpen Access
Table 9, SAR of Selected Compounds as Mouse CXCR6 Antagonists
2014
Table 1, Potency and selectivity characteristics for probe ML339 for antagonist activity
2014
Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis
Europe PMC (PubMed Central)·2014· 5 cited
Imidazole-derived agonists for the neurotensin 1 receptor
Bioorganic & Medicinal Chemistry Letters·2013· 17 citedOpen Access
Preparative Microfluidic Electrosynthesis of Drug Metabolites
ACS Medicinal Chemistry Letters·2013· 91 citedOpen Access
Discovery of ML314, a Brain Penetrant Nonpeptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor
ACS Medicinal Chemistry Letters·2013· 48 citedOpen Access
Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway
Beilstein Journal of Organic Chemistry·2013· 7 citedOpen Access
Continuous-Flow Microfluidic Electrochemical Synthesis: Investigating a New Tool for Oxidative Chemistry
Journal of Flow Chemistry·2013· 46 cited
[Figure], 13C NMR Spectrum of ML304 (125 MHz, CDCl3)
2013
Figure 1, Structure of ML304
2013
Figure 2, Stability of ML304 in (△) PBS or (●) 1:1 acetonitrile:PBS at room temperature
2013
A 2nd Selective Inhibitor of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase (PfG6PDH) - Probe 2
Europe PMC (PubMed Central)·2013· 5 cited
[Figure], 1H NMR Spectrum of ML304 (500 MHz, CDCl3)
2013
Table 2, Hydrolytic stability of ML304 at ambient temperature
2013
Figure 4, Profile of ML304 against the Psychoactive Drug Screening Program (PDSP) % inhibition at 10 μM
2013
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Frequent Co-authors

Satyamaheshwar Peddibhotla(8), Ying Su(7), Layton H. Smith(7), Hnin Hnin Khine(6), Steven S. Pullen(6), Michael Vicchiarelli(6), John P. Wolak(5), John C. Reed(5), Arianna Mangravita-Novo(5), Hidenori Takahashi(5), Vittorio Farina(4), Noel S. Wilson(4), Christopher R. Sarko(4), Romain Stalder(4), Eliot Sugarman(4), Mohammed A. Kashem(4), Josephine King(4), Michael P. Winters(4), Pasha M. Khan(4), Palak Gosalia(4)