John P. Wolak

Boehringer Ingelheim (United States) — United States

Chemistry · Physical Sciences

10h-index503citations12works0.02yr avg
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Research Topics

Quinazolinone synthesis and applications(4), Protein Kinase Regulation and GTPase Signaling(3), Cell Adhesion Molecules Research(2), CAR-T cell therapy research(2), Cytokine Signaling Pathways and Interactions(2)

Publications12 total

A High-Throughput Scintillation Proximity Assay for Sphingosine-1-Phosphate Lyase
Assay and Drug Development Technologies·2014· 12 cited
Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinases and Crystallographic Studies Revealing an Unusual Kinase Binding Mode
Journal of Medicinal Chemistry·2009· 69 citedOpen Access
Corrigendum to “Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)” [Bioorg. Med. Chem. Lett. 18 (2008) 5545–5549]
Bioorganic & Medicinal Chemistry Letters·2009· 3 cited
Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design
Bioorganic & Medicinal Chemistry Letters·2008· 33 citedOpen Access
2-Aminobenzimidazoles as potent ITK antagonists: de novo design of a pyrrole system targeting additional hydrogen bonding interaction
Tetrahedron Letters·2008· 19 cited
5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)
Bioorganic & Medicinal Chemistry Letters·2008· 24 citedOpen Access
Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)
Bioorganic & Medicinal Chemistry Letters·2008· 32 citedOpen Access
Hit-to-lead studies on benzimidazole inhibitors of ITK: Discovery of a novel class of kinase inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 65 citedOpen Access
Three Mechanistically Distinct Kinase Assays Compared: Measurement of Intrinsic ATPase Activity Identified the Most Comprehensive Set of ITK Inhibitors
SLAS DISCOVERY·2006· 132 citedOpen Access
Discovery of potent and selective PKC-θ inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 69 citedOpen Access
Optimization of 2-Phenylaminoimidazo[4,5-<i>h</i>]isoquinolin-9-ones:  Orally Active Inhibitors of lck Kinase
Journal of Medicinal Chemistry·2003· 45 citedOpen Access
5432449 Test apparatus for magnetic resonance imaging systems
Magnetic Resonance Imaging·1995

Frequent Co-authors

Mohammed A. Kashem(9), Steven S. Pullen(7), Hnin Hnin Khine(6), Gregory P. Roth(6), Hidenori Takahashi(6), Joseph R. Woska(5), Anthony S. Prokopowicz(4), Roger J. Snow(4), Charles L. Cywin(4), Michael P. Winters(4), André White(4), Carol Homon(3), Scott Jakes(3), Ronald L. Magolda(3), Deborah D. Jeanfavre(3), Josephine King(3), Brian N. Cook(3), Peter Nemoto(3), K.J.M. Moriarty(3), Ernest Raymond(3)