Joseph R. Woska

Boehringer Ingelheim (United States) — United States

Medicine · Health Sciences

19h-index1.1kcitations29works0.02yr avg
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Research Topics

Cell Adhesion Molecules Research(11), Monoclonal and Polyclonal Antibodies Research(6), Immune Response and Inflammation(5), Immunotherapy and Immune Responses(4), Immune Cell Function and Interaction(4)

Publications29 total

Abstract 1478: Human transgenic IL-15 NOG mice reconstituted with human NK cells as a model for NK cell depletion
Cancer Research·2019
Abstract 1478: Human transgenic IL-15 NOG mice reconstituted with human NK cells as a model for NK cell depletion
Immunology·2019
Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5)
mAbs·2019· 8 citedOpen Access
Impedance-Based Assessment of Preclinical Cardiac Structural Toxicity Using Human iPSC-Derived Cardiomyocytes and its Correlation to In Vivo (dog) Exposures
Journal of Pharmacological and Toxicological Methods·2017
Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies
mAbs·2017· 84 citedOpen Access
An impedance-based approach using human iPSC-derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities
Toxicology and Applied Pharmacology·2017· 34 cited
Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor
Journal of Biological Chemistry·2015· 29 citedOpen Access
SNARE complex‐mediated degranulation in mast cells
Journal of Cellular and Molecular Medicine·2011· 44 citedOpen Access
Small‐Interfering RNA‐Mediated Identification and Regulation of the Ternary SNARE Complex Mediating RBL‐2H3 Mast Cell Degranulation
Scandinavian Journal of Immunology·2010· 33 cited
Corrigendum to “Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)” [Bioorg. Med. Chem. Lett. 18 (2008) 5545–5549]
Bioorganic & Medicinal Chemistry Letters·2009· 3 cited
5-Aminomethylbenzimidazoles as potent ITK antagonists
Bioorganic & Medicinal Chemistry Letters·2009· 44 citedOpen Access
Inhibition of pro-inflammatory cytokine production by the dual p38/JNK2 inhibitor BIRB796 correlates with the inhibition of p38 signaling
Biochemical Pharmacology·2008· 28 cited
2-Aminobenzimidazoles as potent ITK antagonists: de novo design of a pyrrole system targeting additional hydrogen bonding interaction
Tetrahedron Letters·2008· 19 cited
2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket
Bioorganic & Medicinal Chemistry Letters·2008· 22 citedOpen Access
5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk)
Bioorganic & Medicinal Chemistry Letters·2008· 24 citedOpen Access
Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)
Bioorganic & Medicinal Chemistry Letters·2008· 32 citedOpen Access
The determination and correlation of molecular and cellular equilibrium Kd and kinetic koff values for small molecule allosteric antagonists of LFA-1
Biochemical Pharmacology·2007· 5 cited
Discovery of potent and selective PKC-θ inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 69 citedOpen Access
Partners in Science: A Model Cooperative Program Introducing High School Teachers and Students to Leading-Edge Pharmaceutical Science
Journal of Science Education and Technology·2005· 1 cited
Overview of Approaches to the Identification of Inhibitors of Cytokine Action
Current Protocols in Pharmacology·2004
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Frequent Co-authors

Deborah D. Jeanfavre(12), Barbara‐Jean Bormann(6), Ernest Raymond(6), Gary Caviness(6), Hnin Hnin Khine(6), Steven S. Pullen(6), Hidenori Takahashi(6), Patricia L. Reilly(5), Robert Rothlein(5), Mohammed A. Kashem(5), John P. Wolak(5), Terence A. Kelly(4), Maurice M. Morelock(4), Gregory P. Roth(4), Ho Yin Lo(4), Elizabeth A. Mainolfi(3), Rajkumar Ganesan(3), Christine Grimaldi(3), Jennifer Ahlberg(3), Su-Ellen Brown(3)