Simone Iwabe

Altair Engineering (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index1.8kcitations76works7.02yr avg
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Research Topics

Retinal Development and Disorders(59), Retinal Diseases and Treatments(17), Virus-based gene therapy research(14), Photoreceptor and optogenetics research(13), Glaucoma and retinal disorders(9)

Publications76 total

Consensus guidelines for nomenclature of companion animal inherited retinal disorders
Veterinary Ophthalmology·2024· 7 citedOpen Access
Photochemical Restoration of Light Sensitivity in the Degenerated Canine Retina
Pharmaceutics·2022· 4 citedOpen Access
Quantitative and qualitative characterization of retinal dystrophies in canine models of inherited retinal diseases using spectral domain optical coherence tomography (SD-OCT)
Experimental Eye Research·2022· 2 citedOpen Access
Targeting ON-bipolar cells by AAV gene therapy stably reverses <i>LRIT3</i> -congenital stationary night blindness
Proceedings of the National Academy of Sciences·2022· 28 citedOpen Access
Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis
Molecular Therapy·2021· 4 citedOpen Access
scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution
eLife·2021· 55 citedOpen Access
Targeting ON-bipolar cells by AAV gene therapy stably reverses <i>LRIT3</i> -congenital stationary night blindness
2021Open Access
Author response: scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution
2021Open Access
Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis
Molecular Therapy·2021· 34 citedOpen Access
Gene Therapy Reforms Photoreceptor Structure and Restores Vision in <i>NPHP5</i> -associated Leber Congenital Amaurosis
2020Open Access
scAAVengr: Single-cell transcriptome-based quantification of engineered AAVs in non-human primate retina
2020· 4 citedOpen Access
AAV capsid variants target canine and primate bipolar cells after subretinal and intravitreal delivery
2020
Focal/multifocal and geographic retinal dysplasia in the dog—In vivo retinal microanatomy analyses
Veterinary Ophthalmology·2019· 12 citedOpen Access
Long-Term Structural Outcomes of Late-Stage RPE65 Gene Therapy
Molecular Therapy·2019· 71 citedOpen Access
Safety and long-term efficacy of AAV2-BEST1 gene augmentation therapy in canine model of Best vitelliform macular dystrophies
Investigative Ophthalmology & Visual Science·2019Open Access
Author Correction: Variabilities in retinal function and structure in a canine model of cone-rod dystrophy associated with RPGRIP1 support multigenic etiology
Scientific Reports·2018Open Access
Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector
Proceedings of the National Academy of Sciences·2018· 142 citedOpen Access
Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis
Investigative Ophthalmology & Visual Science·2018· 1 citedOpen Access
AAV-mediated expression of X-linked Inhibitor of Apoptosis protects photoreceptors in two canine models of early onset RP
Investigative Ophthalmology & Visual Science·2018Open Access
BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments
Investigative Ophthalmology & Visual Science·2018Open Access
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Frequent Co-authors

William A. Beltran(29), Geoffrey K. Aguirre(22), William W. Hauswirth(21), Artur V. Cideciyan(18), Samuel G. Jacobson(18), András M. Komáromy(17), Gustavo D. Aguirre(17), Valérie Dufour(15), Sanford L. Boye(14), Małgorzata Świder(13), Alexander Sumaroka(7), Alfred S. Lewin(7), Karina E Guziewicz(7), Raghavi Sudharsan(5), Luis Felipe Marinho(5), Gui‐Shuang Ying(5), Barbara Zangerl(5), Sem Genini(4), Erin M. Scott(4), Kendra S. McDaid(4)