Mahmoud H. el Kouni

University of Alabama at Birmingham — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index2.9kcitations100works0.02yr avg
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Research Topics

Biochemical and Molecular Research(63), Toxoplasma gondii Research Studies(18), Pancreatic and Hepatic Oncology Research(11), Parasites and Host Interactions(11), Cytomegalovirus and herpesvirus research(11)

Publications100 total

Kinetics mechanism and regulation of native human hepatic thymidine phosphorylase
The International Journal of Biochemistry & Cell Biology·2019· 1 cited
Enzymes of pyrimidine salvage pathways in intraerythrocytic Plasmodium falciparum
The International Journal of Biochemistry & Cell Biology·2018· 5 cited
Distinct substrate specificity and physicochemical characterization of native human hepatic thymidine phosphorylase
PLoS ONE·2018· 4 citedOpen Access
Determinants for Genital Human Papillomavirus (HPV) Infection in Tunisian Women with Normal Pap smear: Are There Different Risk Profiles for Oncogenic and Nononcogenic HPV Types?
Iproceedings·2018Open Access
Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets
Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology·2017· 33 cited
Abstract 2159: <i>In vitro</i> characterization of PTAU and FU interactions in colon cancer cells
Cancer Research·2016
Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine
Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology·2015· 5 citedOpen Access
Nucleoside kinases in adult Schistosoma mansoni: Phosphorylation of pyrimidine nucleosides
Molecular and Biochemical Parasitology·2014· 2 cited
Isolation and substrate specificity of an adenine nucleoside phosphorylase from adult Schistosoma mansoni
Molecular and Biochemical Parasitology·2014· 5 citedOpen Access
Effect of Mimetic CDK9 Inhibitors on HIV-1-Activated Transcription
Journal of Molecular Biology·2012· 42 cited
Potent combination therapy for human breast tumors with high doses of 5-fluorouracil: remission and lack of host toxicity
Cancer Chemotherapy and Pharmacology·2012· 6 cited
Paracrine Stimulation of Endothelial Cell Motility and Angiogenesis by Platelet-Derived Deoxyribose-1-Phosphate
Arteriosclerosis Thrombosis and Vascular Biology·2010· 16 citedOpen Access
Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: Biological activities and selective toxicities
Biochemical Pharmacology·2010· 17 citedOpen Access
Structure–activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase
Bioorganic & Medicinal Chemistry·2010· 18 citedOpen Access
7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities
Biochemical Pharmacology·2008· 35 citedOpen Access
Structure−Activity Relationships of 7-Deaza-6-benzylthioinosine Analogues as Ligands of<i>Toxoplasma gondii</i>Adenosine Kinase
Journal of Medicinal Chemistry·2008· 37 citedOpen Access
Uridine Protects Cortical Neurons from Glucose Deprivation-Induced Death: Possible Role of Uridine Phosphorylase
Journal of Neurotrauma·2008· 45 cited
Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity
Cancer Chemotherapy and Pharmacology·2007· 8 cited
Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents
Biochemical Pharmacology·2007· 36 citedOpen Access
Substrate analogs induce an intermediate conformational change in<i>Toxoplasma gondii</i>adenosine kinase
Acta Crystallographica Section D Biological Crystallography·2007· 16 cited
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Frequent Co-authors

Fardos N.M. Naguib(29), Sungman Cha(17), Omar N. Al Safarjalani(9), Max H. Iltzsch(7), Chung K. Chu(7), Shih Hsi Chu(6), Raymond P. Panzica(6), Reem H. Rais(6), John G. Niedzwicki(5), Vincenzo Guarcello(3), Young Ah Kim(3), William J. Sullivan(2), David S. Roos(2), Craig M. Wilson(2), Mustapha M. el Kouni(2), Diane L. Levesque(2), Raymond F. Schinazi(2), Naganna M. Goudgaon(2), Daisy Akerey Diop(2), Vikas Yadav(2)