Leah Aluisio

Janssen (United States) — United States

Neuroscience · Life Sciences

27h-index2.5kcitations45works0.02yr avg
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Research Topics

Sleep and Wakefulness Research(12), Receptor Mechanisms and Signaling(12), Neuroscience and Neuropharmacology Research(10), Mast cells and histamine(10), Circadian rhythm and melatonin(8)

Publications44 total

The effects of intranasal esketamine on on-road driving performance in patients with major depressive disorder or persistent depressive disorder
Journal of Psychopharmacology·2022· 14 citedOpen Access
Esketamine Nasal Spray Plus Oral Antidepressant in Patients With Treatment-Resistant Depression
The Journal of Clinical Psychiatry·2020· 265 citedOpen Access
Managing Esketamine Treatment Frequency Toward Successful Outcomes: Analysis of Phase 3 Data
The International Journal of Neuropsychopharmacology·2020· 17 citedOpen Access
142 Withdrawal Symptom Assessment in an Esketamine Safety Study in Patients with Treatment-resistant Depression
CNS Spectrums·2020· 3 citedOpen Access
P.033 Managing esketamine treatment frequency toward successful outcomes: Analysis of phase 3 data
European Neuropsychopharmacology·2019· 1 cited
P.327 Withdrawal symptom assessment in an esketamine safety study in patients with treatment-resistant depression
European Neuropsychopharmacology·2019· 1 cited
Etude de phase 3 en ouvert évaluant l’efficacité et la sécurité d’emploi à long terme d’Eskétamine intranasal (ESK IN) associé à un antidépresseur oral chez des patients atteints de dépression résistante (SUSTAIN-2)
French Journal of Psychiatry·2018
Utilizing Miniature Fluorescence Microscopy to Image Hippocampal Place Cell Ensemble Function in Thy1.GCaMP6f Transgenic Mice
Current Protocols in Pharmacology·2018· 4 cited
Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia
Neuropsychopharmacology·2018· 75 citedOpen Access
A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1<i>H</i>-[1,2,3]triazolo[4,5-<i>c</i>]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate
Journal of Medicinal Chemistry·2017· 73 citedOpen Access
4-Methyl-6,7-dihydro-4<i>H</i>-triazolo[4,5-<i>c</i>]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate
Journal of Medicinal Chemistry·2017· 65 citedOpen Access
Direct Imaging of Hippocampal Epileptiform Calcium Motifs Following Kainic Acid Administration in Freely Behaving Mice
Frontiers in Neuroscience·2016· 34 citedOpen Access
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia
Journal of Pharmacology and Experimental Therapeutics·2015· 80 cited
Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development
ACS Medicinal Chemistry Letters·2015· 17 citedOpen Access
Zolpidem Reduces Hippocampal Neuronal Activity in Freely Behaving Mice: A Large Scale Calcium Imaging Study with Miniaturized Fluorescence Microscope
PLoS ONE·2014· 33 citedOpen Access
Pharmacology of a Novel Central Nervous System–Penetrant P2X7 Antagonist JNJ-42253432
Journal of Pharmacology and Experimental Therapeutics·2014· 72 cited
Pharmacological or genetic orexin1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex
Frontiers in Neuroscience·2014· 8 citedOpen Access
Pharmacological characterization of a novel centrally permeable <scp>P2X7</scp> receptor antagonist: <scp>JNJ</scp>‐47965567
British Journal of Pharmacology·2013· 191 citedOpen Access
Translational Evaluation of JNJ-18038683, a 5-Hydroxytryptamine Type 7 Receptor Antagonist, on Rapid Eye Movement Sleep and in Major Depressive Disorder
Journal of Pharmacology and Experimental Therapeutics·2012· 83 cited
Evaluating PK/PD Relationship of CNS Drug by Using Liquid Chromtography/ Tandem Mass Spectrometry Coupled to In Vivo Microdialysis
InTech eBooks·2012· 3 citedOpen Access
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Frequent Co-authors

Timothy W. Lovenberg(33), Pascal Bonaventure(26), Brian Lord(25), Nicholas I. Carruthers(24), Ian Fraser(23), Christine Dugovic(16), Michael A. Letavic(14), Jamin D. Boggs(12), Jonathan Shelton(9), Jaskaran Singh(8), Curt A. Dvorak(8), James R. Shoblock(8), Ann Barbier(8), Diane Nepomuceno(7), Ruggero Galici(7), Curt Mazur(7), Sandy J. Wilson(6), Lisa Dvorak(6), Ewa Wajs(5), Ella Daly(5)