Christine Dugovic

Neuroscience · Life Sciences

33h-index4.1kcitations73works0.02yr avg
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Research Topics

Sleep and Wakefulness Research(48), Circadian rhythm and melatonin(28), Sleep and related disorders(19), Neuroscience and Neuropharmacology Research(12), Receptor Mechanisms and Signaling(12)

Publications72 total

PS-Inducing Factors And The Noradrenergic System
2024
Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans
Translational Psychiatry·2020· 46 citedOpen Access
Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models
European Journal of Pharmacology·2020· 4 cited
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793
ACS Medicinal Chemistry Letters·2020· 8 citedOpen Access
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor
Journal of Pharmacology and Experimental Therapeutics·2019· 28 citedOpen Access
Endocannabinoids and sleep: impact of monoacylglycerol lipase inhibition in rodent models
Sleep Medicine·2019
S170. In Vivo Characterization of an Orally Available, Brain Penetrant Small Molecule GPR139 Agonist
Biological Psychiatry·2018
Emerging role of GPR139 on sleep modulation and stress response in rodent models
Proceedings for Annual Meeting of The Japanese Pharmacological Society·2018Open Access
Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation
2017
Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation
Frontiers in Pharmacology·2017· 46 citedOpen Access
Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice
Frontiers in Behavioral Neuroscience·2017· 24 citedOpen Access
Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8
Journal of Pharmacology and Experimental Therapeutics·2016· 97 cited
Direct Imaging of Hippocampal Epileptiform Calcium Motifs Following Kainic Acid Administration in Freely Behaving Mice
Frontiers in Neuroscience·2016· 34 citedOpen Access
GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids l-Tryptophan and l-Phenylalanine
Molecular Pharmacology·2015· 72 cited
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia
Journal of Pharmacology and Experimental Therapeutics·2015· 80 cited
Novel Octahydropyrrolo[3,4-<i>c</i>]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate
Journal of Medicinal Chemistry·2015· 41 citedOpen Access
Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development
ACS Medicinal Chemistry Letters·2015· 17 citedOpen Access
Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity
Frontiers in Behavioral Neuroscience·2015· 16 citedOpen Access
A Selective Orexin-1 Receptor Antagonist Attenuates Stress-Induced Hyperarousal without Hypnotic Effects
Journal of Pharmacology and Experimental Therapeutics·2015· 96 citedOpen Access
Zolpidem Reduces Hippocampal Neuronal Activity in Freely Behaving Mice: A Large Scale Calcium Imaging Study with Miniaturized Fluorescence Microscope
PLoS ONE·2014· 33 citedOpen Access
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Frequent Co-authors

Timothy W. Lovenberg(23), Pascal Bonaventure(22), Brian Lord(17), Jonathan Shelton(15), Nicholas I. Carruthers(13), Leah Aluisio(12), Sujin Yun(12), Fred W. Turek(10), Ian Fraser(8), A. Wauquier(8), Michael A. Letavic(8), Diane Nepomuceno(8), Aaron D. Laposky(6), Brock T. Shireman(6), Curt A. Dvorak(5), Steven W. Sutton(4), Ann Barbier(4), Michelle Wennerholm(4), Tatiana Koudriakova(4), Kirsten L. Miller(3)