Diane Nepomuceno

Janssen (United States) — United States

Neuroscience · Life Sciences

24h-index2.1kcitations56works4.02yr avg
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Research Topics

Neuropeptides and Animal Physiology(17), Receptor Mechanisms and Signaling(17), Sleep and Wakefulness Research(12), Circadian rhythm and melatonin(10), Pregnancy-related medical research(10)

Publications56 total

In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
Cellular and Molecular Life Sciences·2024· 4 citedOpen Access
In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
2023· 1 citedOpen Access
Identification and characterization of select oxysterols as ligands for GPR17
British Journal of Pharmacology·2022· 21 citedOpen Access
Identification and characterization of select oxysterols as ligands for Gpr17
2022Open Access
Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7/2 inhibitors leading to the identification of a clinical candidate
Bioorganic & Medicinal Chemistry Letters·2020· 3 citedOpen Access
Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans
Translational Psychiatry·2020· 46 citedOpen Access
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793
ACS Medicinal Chemistry Letters·2020· 8 citedOpen Access
Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors
Pharmacology Research & Perspectives·2019· 5 citedOpen Access
Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro
Frontiers in Pharmacology·2018· 16 citedOpen Access
Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation
2017
Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation
Frontiers in Pharmacology·2017· 46 citedOpen Access
GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids l-Tryptophan and l-Phenylalanine
Molecular Pharmacology·2015· 72 cited
Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor
ACS Medicinal Chemistry Letters·2015· 35 citedOpen Access
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia
Journal of Pharmacology and Experimental Therapeutics·2015· 80 cited
Novel Octahydropyrrolo[3,4-<i>c</i>]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate
Journal of Medicinal Chemistry·2015· 41 citedOpen Access
A Selective Orexin-1 Receptor Antagonist Attenuates Stress-Induced Hyperarousal without Hypnotic Effects
Journal of Pharmacology and Experimental Therapeutics·2015· 96 citedOpen Access
Pharmacological characterization of a novel centrally permeable <scp>P2X7</scp> receptor antagonist: <scp>JNJ</scp>‐47965567
British Journal of Pharmacology·2013· 191 citedOpen Access
The discovery of potent selective NPY Y2 antagonists
Bioorganic & Medicinal Chemistry Letters·2013· 2 citedOpen Access
Translational Evaluation of JNJ-18038683, a 5-Hydroxytryptamine Type 7 Receptor Antagonist, on Rapid Eye Movement Sleep and in Major Depressive Disorder
Journal of Pharmacology and Experimental Therapeutics·2012· 83 cited
In vitro pharmacological characterization of RXFP3 Allosterism: an example of probe dependency
The FASEB Journal·2012· 3 cited
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Frequent Co-authors

Pascal Bonaventure(42), Timothy W. Lovenberg(40), Nicholas I. Carruthers(22), Brian Lord(17), Changlu Liu(16), Chester Kuei(15), Steven W. Sutton(14), Curt A. Dvorak(11), Christine Dugovic(10), Michael A. Letavic(8), Jonathan Shelton(8), Lisa Dvorak(8), Jing‐Cai Chen(7), Ian Fraser(7), Brock T. Shireman(7), Dale A. Rudolph(7), Leah Aluisio(6), Jiejun Wu(5), Jessica Zhu(5), Elo Eriste(5)