Diana Lamppu

Biochemistry, Genetics and Molecular Biology · Life Sciences

7h-index368citations10works0.02yr avg
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Research Topics

Metabolism and Genetic Disorders(4), Nicotinic Acetylcholine Receptors Study(3), Cancer-related Molecular Pathways(2), Receptor Mechanisms and Signaling(2), Diet and metabolism studies(2)

Publications10 total

The pheNIX trial: first-in-human gene therapy trial for PKU due to phenylalanine hydroxylase (PAH) deficiency
Molecular Genetics and Metabolism·2021
Sustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH
Molecular Therapy — Methods & Clinical Development·2020· 29 citedOpen Access
5-year retrospective analysis of patients with phenylketonuria (PKU) and hyperphenylalaninemia treated at two specialized clinics
Molecular Genetics and Metabolism·2019· 24 citedOpen Access
Single intravenous dose of AAVHSC15 vector with human phenylalanine hydroxylase transgene results in sustained correction of phenylketonuria in the PAH mouse model
Molecular Genetics and Metabolism·2019
Two Novel α7 Nicotinic Acetylcholine Receptor Ligands: In Vitro Properties and Their Efficacy in Collagen-Induced Arthritis in Mice
PLoS ONE·2015· 44 citedOpen Access
Discovery of Novel 2-((Pyridin-3-yloxy)methyl)piperazines as α7 Nicotinic Acetylcholine Receptor Modulators for the Treatment of Inflammatory Disorders
Journal of Medicinal Chemistry·2014· 33 citedOpen Access
ANTI-INFLAMMATORY EFFECTS OF AN ALPHA-7 NICOTINIC CHOLINERGIC RECEPTOR AGONIST IN MURINE MODELS OF ENDOTOXEMIA
Shock·2006
Identification of 2-{2-[2-(5-Bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl}-4,5-dihydro-1<i>H</i>-imidazole (ML00253764), a Small Molecule Melanocortin 4 Receptor Antagonist That Effectively Reduces Tumor-Induced Weight Loss in a Mouse Model
Journal of Medicinal Chemistry·2004· 100 citedOpen Access
The interaction of taxol and vinblastine with radiation induction of p53 and p21 WAF1/CIP1.
PubMed·1996· 13 cited
Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53.
PubMed·1995· 125 cited

Frequent Co-authors

Daniel Elbaum(3), Albert Seymour(3), Roy B. Tishler(2), Roger B. Clark(2), Lyn Libertine(2), Seemin Seher Ahmed(2), Hillard Rubin(2), Deiby Faulkner(2), Arnold Sengooba(2), Serena Dollive(2), Jeff L. Ellsworth(2), Teresa L. Wright(2), Omar L. Francone(2), Sujin Park(1), Brendan D. Price(1), Tricia J. Vos(1), Andrei Caracoti(1), L. McGlothan Jennifer(1), Mingshi Dai(1), Cheryl A. Farrer(1)