Jessica Nagel

University of Bonn — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

5h-index126citations20works2.62yr avg
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Research Topics

Adenosine and Purinergic Signaling(9), Pharmacological Receptor Mechanisms and Effects(5), Protein Kinase Regulation and GTPase Signaling(4), Receptor Mechanisms and Signaling(4), Neuropeptides and Animal Physiology(3)

Publications20 total

Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor
Nature Communications·2025· 1 citedOpen Access
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor
Nature Communications·2025· 3 citedOpen Access
UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design
2025· 1 citedOpen Access
BPS2025 - Molecular pharmacology of human P2X7 receptor ligands visualized by cryo-EM
Biophysical Journal·2025
Species Differences of P2X4 Receptor Modulators
ACS Pharmacology & Translational Science·2025· 3 citedOpen Access
Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy
Journal of Medicinal Chemistry·2024· 9 citedOpen Access
Correction to: Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist
Purinergic Signalling·2024Open Access
Preparation and preliminary evaluation of a tritium-labeled allosteric P2X4 receptor antagonist
Purinergic Signalling·2024· 4 citedOpen Access
Structural response of G protein binding to the cyclodepsipeptide inhibitor FR900359 probed by NMR spectroscopy
Chemical Science·2024· 2 citedOpen Access
Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates
Nature Chemistry·2023· 30 citedOpen Access
Practical Stereocontrolled Access to Thioisosteres of Essential Signaling Molecules and Building Blocks for Life: Nucleoside Di- and Triphosphates
2022· 1 citedOpen Access
Extracellular binding sites of positive and negative allosteric P2X4 receptor modulators
Life Sciences·2022· 19 cited
Extracellular Binding Sites of Positive and Negative Allosteric P2X4 Receptor Modulators
SSRN Electronic Journal·2022Open Access
Consulting 4.0
2022
Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors
Pharmacological Research·2021· 16 citedOpen Access
Initial structures of macrocyclic Gαq protein inhibitors bound to the Gq heterotrimer
2021Open Access
Initial structures of macrocyclic Gαq protein inhibitors bound to the Gq heterotrimer
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Asbestos anger: It was a straight forward Foxtel setup, but the installer accidentally drilled through the ceiling, exposing the Morse family to asbestos.
2020
Effect of Two Equipment Load Bearing Strategies on Low Back Discomfort in On-duty Police Officers
Medicine & Science in Sports & Exercise·2019
Decreasing body dissatisfaction using a brief conditioning intervention
Behaviour Research and Therapy·2015· 37 citedOpen Access

Frequent Co-authors

Christa E. Müller(16), Vigneshwaran Namasivayam(6), Aliaa Abdelrahman(6), Gabriele M. König(4), Yong‐Chul Kim(4), Stephanie Weinhausen(3), Jan Voss(3), Muhammad Rafehi(3), Ramón Guixà-González(3), Davide Malfacini(3), Julian Patt(3), Stefan Kehraus(3), Asuka Inoue(3), Evi Kostenis(3), Xavier Deupí(3), Garam Kim(3), Christiane Bous(3), Anke C. Schiedel(3), Adam Oken(3), Andreea L. Turcu(3)