Richard S. Lewis

Stanford University — United States

Neuroscience · Life Sciences

60h-index25.4kcitations140works0.82yr avg
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Research Topics

Ion Channels and Receptors(60), Ion channel regulation and function(43), Neurobiology and Insect Physiology Research(24), Neuroscience and Neuropharmacology Research(16), Phytochemicals and Antioxidant Activities(14)

Publications140 total

Structural rearrangements underlying the activation of STIM1 by ER calcium depletion
2026Open Access
Multiple weak brakes act in concert to control STIM1 and store-operated calcium entry
Proceedings of the National Academy of Sciences·2025· 2 citedOpen Access
Multiple weak brakes act in concert to regulate STIM1 and control store-operated calcium entry
2025· 1 citedOpen Access
BPS2025 - Mechanistic study of STIM1 activation using single-molecule FRET and AlphaFold2
Biophysical Journal·2025
Editor's evaluation: Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+
2022Open Access
Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function
Nature Communications·2022· 36 citedOpen Access
Culture and Self-Construal
Oxford University Press eBooks·2022· 2 cited
Author response: Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
2021Open Access
Editor's evaluation: S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse
2021Open Access
Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
2020· 3 citedOpen Access
Editor's evaluation: Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes
2020Open Access
Decision letter: A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore
2020Open Access
Store-Operated Calcium Channels: From Function to Structure and Back Again
Cold Spring Harbor Perspectives in Biology·2019· 120 citedOpen Access
Numbers count: How STIM and Orai stoichiometry affect store-operated calcium entry
Cell Calcium·2019· 48 citedOpen Access
Structural features of STIM and Orai underlying store-operated calcium entry
Current Opinion in Cell Biology·2019· 51 citedOpen Access
Multiple Papules on an Elderly Man
American Journal of Dermatopathology·2019
Decision letter: A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia
2018Open Access
Universal intracellular biomolecule delivery with precise dosage control
Science Advances·2018· 122 citedOpen Access
Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits
The Journal of General Physiology·2018· 31 citedOpen Access
Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel
Biophysical Journal·2016· 78 citedOpen Access
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Frequent Co-authors

Murali Prakriya(8), Ricardo E. Dolmetsch(7), Michael D. Cahalan(7), Minnie M. Wu(5), Adam Zweifach(4), Markus Hoth(4), Anjana Rao(3), Christopher C. Goodnow(3), James I. Healy(3), Elizabeth D. Covington(3), Riina M. Luik(3), A. J. Hudspeth(3), Stefan Feske(2), Patrick G. Hogan(2), Chan Young Park(2), Paul Hoover(2), Franklin M. Mullins(2), JoAnn Buchanan(2), Joseph C. Wu(2), Christopher M. Fanger(2)